Figure 7.

Wound closure in wild type mice (WT), Il36rn^−/− mice (KO), and KO treated with TAK-242 (KO + TAK) at 3 and 7 days after wounding. (A) Representative photographs of open wounds in WT, KO, and TAK. (B) Areas of open wound were measured at 3 and 7 days after wounding. (C) Numbers of neutrophils at 3 days after wounding per section were determined by counting H&E-stained sections under the microscope. Each histogram shows the mean ± SEM values obtained from 3 mice (12 wounds) in the WT group, and 3 mice (12 wounds) in KO group, and 3 mice (12 wounds) in TAK group (*p < 0.05; ***p < 0.001).