Figure 2.

Measured and Estimated Metabolic Concentrations and Mass Isotopomer Fractions in the Ins and Control Ctrl Conditions

The circles and the error bars indicate the mean and the standard deviations of the measurements from three separate experiments (Krycer et al., 2017). The lines and the shaded areas indicate optimal estimates with the 90% confidence intervals for the values calculated with the model. M + i indicates mass isotopomer with i carbons labeled with ¹³C. Note that media were exchanged at 0 min in both conditions. All measured and estimated metabolites concentrations and their mass isotopomer fractions are shown in Figure S2, metabolites are defined in Table S1, and estimated concentrations are shown in Table S2 and Data S1.