Table 1.
Effect of protocol on venous pH and pCO2 in mice
| Sex | Protocol | N obs | Mean pH ±SD | Mean pCO2 ±SD mm Hg | Normal 7.35 < pH ≤7.45 | Mild Acidosis 7.25 <pH ≤ 7.35 | Moderate Acidosis 7.15 <pH ≤ 7.25 | Severe Acidosis pH ≤ 7.15 | |
| Balb/c | |||||||||
| EX | 16 | 7.351 ± 0.029 | 32.619 ± 4.872 | 7(43.8%) | 9(56.3%) | . | . | ||
| KX | 17 | 7.350 ± 0.036 | 35.835 ± 7.528 | 9(52.9%) | 8(47.1%) | . | . | ||
| F | EX | 8 | 7.336 ± 0.026 | 32.450 ± 5.600 | 1(12.5%) | 7(87.5%) | . | . | |
| KX | 8 | 7.380 ± 0.022 | 30.088 ± 3.835 | 7(87.5%) | 1(12.5%) | . | . | ||
| M | EX | 8 | 7.366 ± 0.024 | 32.788 ± 4.409 | 6(75.0%) | 2(25.0%) | . | . | |
| KX | 9 | 7.324 ± 0.023 | 40.944 ± 6.170 | 2(22.2%) | 7(77.8%) | . | . | ||
| C57BL/6 | |||||||||
| EX | 17 | 7.320 ± 0.087 | 37.300 ± 6.709 | 8(47.1%) | 7(41.2%) | 1(5.9%) | 1(5.9%) | ||
| KX | 17 | 7.338 ± 0.043 | 42.900 ± 8.068 | 7(41.2%) | 10(58.8%) | . | . | ||
| F | EX | 9 | 7.287 ± 0.110 | 36.544 ± 7.685 | 2(22.2%) | 5(55.6%) | 1(11.1%) | 1(11.1%) | |
| KX | 9 | 7.365 ± 0.023 | 38.656 ± 5.435 | 6(66.7%) | 3(33.3%) | . | . | ||
| M | EX | 8 | 7.357 ± 0.027 | 38.150 ± 5.816 | 6(75.0%) | 2(25.0%) | . | . | |
| KX | 8 | 7.308 ± 0.041 | 47.675 ± 8.111 | 1(12.5%) | 7(87.5%) | . | . | ||
| CD1 | |||||||||
| EX | 16 | 7.323 ± 0.051 | 39.406 ± 5.188 | 3(18.8%) | 11(68.8%) | 2(12.5%) | . | ||
| KX | 17 | 7.362 ± 0.053 | 39.091 ± 6.252 | 12(70.6%) | 4(23.5%) | 1(5.9%) | . | ||
| F | EX | 8 | 7.320 ± 0.056 | 38.525 ± 5.538 | 1(12.5%) | 6(75.0%) | 1(12.5%) | . | |
| KX | 9 | 7.346 ± 0.060 | 40.716 ± 6.110 | 6(66.7%) | 2(22.2%) | 1(11.1%) | . | ||
| M | EX | 8 | 7.326 ± 0.050 | 40.288 ± 5.023 | 2(25.0%) | 5(62.5%) | 1(12.5%) | . | |
| KX | 8 | 7.382 ± 0.039 | 37.263 ± 6.281 | 6(75.0%) | 2(25.0%) | . | . | ||
| NU | |||||||||
| EX | 16 | 7.294 ± 0.054 | 37.769 ± 6.380 | 2(12.5%) | 11(68.8%) | 3(18.8%) | . | ||
| KX | 17 | 7.334 ± 0.056 | 42.624 ± 7.644 | 7(41.2%) | 8(47.1%) | 2(11.8%) | . | ||
| F | EX | 8 | 7.299 ± 0.054 | 39.000 ± 5.739 | 1(12.5%) | 6(75.0%) | 1(12.5%) | . | |
| KX | 9 | 7.373 ± 0.031 | 39.767 ± 6.896 | 7(77.8%) | 2(22.2%) | . | . | ||
| M | EX | 8 | 7.289 ± 0.058 | 36.538 ± 7.130 | 1(12.5%) | 5(62.5%) | 2(25.0%) | . | |
| KX | 8 | 7.291 ± 0.045 | 45.838 ± 7.544 | . | 6(75.0%) | 2(25.0%) | . | ||
| Total | |||||||||
| F | EX | 33 | 7.310 ± 0.069 | 36.627 ± 6.497 | 5(15.2%) | 24(72.7%) | 3(9.1%) | 1(3.0%) | |
| KX | 35 | 7.365 ± 0.038 | 37.513 ± 6.880 | 26(74.3%) | 8(22.9%) | 1(2.9%) | . | ||
| M | EX | 32 | 7.334 ± 0.051 | 36.941 ± 6.080 | 15(46.9%) | 14(43.8%) | 3(9.4%) | . | |
| KX | 33 | 7.326 ± 0.049 | 42.870 ± 7.866 | 9(27.3%) | 22(66.7%) | 2(6.1%) | . | ||
| All | |||||||||
| EX | 65 | 7.322 ± 0.062 | 36.782 ± 6.248 | 20(30.8%) | 38(58.5%) | 6(9.2%) | 1(1.5%) | ||
| KX | 68 | 7.346 ± 0.048 | 40.112 ± 7.800 | 35(51.5%) | 30(44.1%) | 3(4.4%) | . |
N obs: number of mice captured in measuring pH.
EX: Etomidate/Xylazine; F: female; KX:Ketamine/Xylazine; M: Male