Table 2.
Serum chemistry values (mean ± standard deviation) for the 3 groups at the various time points
| Control |
Bup |
BupSR |
BupHC |
||||||||
| 0 h (n = 8) | 96 h (n = 9) | 0 h (n = 5) | 48 h (n = 7) | 96 h (n = 7) | 0 h (n = 8) | 48 h (n = 8) | 96 h (n = 8) | 0 h (n = 7) | 48 h (n = 7) | 96 h (n = 6) | |
| Glucose (mg/dL) | 135.9 ± 4.8 | 145.6 ± 16.4 | 136.6 ± 2.3 | 129.7 ± 6.0 | 128.0 ± 6.9 | 132.8 ± 7.1 | 130.3 ± 6.1 | 135.5 ± 7.5 | 137.0 ± 7.7 | 148.1 ± 40.2 | 151.8 ± 18.2 |
| BUN (mg/dL) | 15.5 ± 1.9 | 13.7 ± 1.3 | 13.6 ± 2.1 | 13.3 ± 4.5 | 13.0 ± 1.6 | 15.9 ± 1.9 | 16.0 ± 4 | 12.9 ± 2.9 | 15.4 ± 1.8 | 17.0 ± 3 | 13.5 ± 2.0 |
| Total protein (g/dL) | 5.2 ± 0.3 | 5.0 ± 0.4 | 5.0 ± 0.4 | 5.4 ± 0.2 | 5.2 ± 0.4 | 5.13 ± 0.2 | 5.5 ± 0.5 | 5.0 ± 0.3 | 5.1 ± 0.2 | 5.5 ± 0.4 | 5.1 ± 0.4 |
| Creatine kinase (U/L) | 378.5 ± 144.1 | 861.3 ± 307.8 | 418.0 ± 217.2 | 4317.1 ± 1442.3 | 1089.9 ± 776.2 | 464.0 ± 194.5 | 7206.3 ± 2723.8 | 931.8 ± 356.8 | 344.1 ± 82.1 | 5382.0 ± 2159.0 | 997.0 ± 817.9 |
| Albumin (g/dL) | 3.9 ± 0.2 | 3.6 ± 0.3 | 3.8 ± 0.3 | 3.9 ± 3.5 | 3.6 ± 0.2 | 3.8 ± 0.1 | 3.6 ± 0.3 | 3.4 ± 0.2 | 3.9 ±0.1 | 3.7 ± 0.3 | 3.5 ± 0.2 |
| Globulin (g/dL) | 1.2 ± 0.2 | 1.3 ± 0.2 | 1.6 ± 0.1 | 1.9 ± 1.9 | 1.6 ± 0.2 | 1.4 ± 0.1 | 1.9 ± 0.2 | 1.6 ± 0.3 | 1.2 ± 0.2 | 1.8 ± 0.3 | 1.6 ± 0.3 |
| Total bilirubin (mg/dL) | 0.1 ± 0.0 | 0.1 ± 0.1 | 0.1 ± 0.0 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.1 ± 0.1 | 0.2 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.1 | 0.2 ± 0.2 | 0.2 ± 0.1 |
| ALP (U/L) | 81.5 ± 29.3 | 55.1 ± 16.9 | 140.2 ± 117.0 | 69.1 ± 58.8 | 57.0 ± 41.3 | 80.1 ± 35.1 | 45.5 ± 25.9 | 43.9 ± 24.2 | 81.9 ± 55.7 | 54.6 ± 27.0 | 47.8 ± 21.5 |
| ALT (U/L) | 23.2 ± 9.0 | 35.7 ± 13.8 | 19.0 ± 6.7 | 41.3 ± 15.0 | 28.0 ± 10.0 | 29.5 ± 10.7 | 69.6 ± 34.3 | 48.9 ± 28.2 | 40.9 ± 37.5 | 60.7 ± 22.0 | 39.0 ± 11.8 |
| AST (U/L) | 11.1 ± 3.4 | 14.4 ± 5.2 | 9.8 ± 2.0 | 26.0 ± 10.3 | 21.0 ± 7.7 | 12.3 ± 3.0 | 41.1 ± 20.2 | 15.1 ± 13.3 | 16.6 ± 7.3 | 38.9 ± 14.9 | 22.1 ± 11.5 |
| Cholesterol (mg/dL) | 35.6 ± 12.4 | 36.3 ± 9.9 | 30.8 ± 6.0 | 50.3 ± 12.7 | 52.3 ± 13.5 | 45.4 ± 41.1 | 57.4 ± 22.5 | 52.8 ± 14.9 | 34.6 ± 6.6 | 55.3 ± 23.7 | 51.2 ± 21.8 |
| Calcium (mg/dL) | 12.8 ± 0.5 | 12.7 ± 0.5 | 12.9 ± 0.5 | 11.6 ± 0.5 | 12.2 ± 0.4 | 13.0 ± 0.4 | 11.8 ± 0.4 | 12.2 ± 0.6 | 11.3 ± 4.8 | 11.8 ± 0.7 | 12.2 ± 0.5 |
| Phosphorus (mg/dL) | 4.5 ± 0.7 | 4.2 ± 0.8 | 4.3 ± 0.4 | 4.3 ± 0.3 | 5.0 ± 0.4 | 4.5 ± 0.5 | 4.4 ± 0.8 | 4.5 ± 0.5 | 4.4 ± 0.7 | 4.4 ± 0.9 | 4.6 ± 0.4 |
| Sodium (mmol/L) | 140.0 ± 1.3 | 141.4 ± 2.3 | 140.0 ± 2.4 | 137.3 ± 2.9 | 139.7 ± 1.1 | 139.5 ± 0.9 | 139.6 ± 4.3 | 140.9 ± 2.0 | 139.4 ± 0.5 | 141.6 ± 2.4 | 140.8 ± 3.0 |
| Potassium (mmol/L) | 4.5 ± 0.1 | 4.5 ± 0.3 | 4.4 ± 0.3 | 5.3 ± 0.8 | 5.0 ± 0.7 | 4.6 ± 0.4 | 5.4 ± 1.1 | 4.6 ± 0.5 | 5.1 ± 2.2 | 5.0 ± 1.1 | 4.9 ± 0.9 |
| Chloride (mmol/L) | 100.8 ± 2.4 | 104.6 ± 2.7 | 103.2 ± 1.3 | 103.1 ± 2.3 | 102.9 ± 1.5 | 101.2 ± 2.8 | 103.4 ± 3.8 | 105.4 ± 2.0 | 100.4 ± 2.5 | 104.1 ± 1.7 | 101.8 ± 2.3 |
| Creatinine (mg/gL) | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 |
| BUN/Creatinine | 18.9 ± 2.5 | 18.3 ±2.9 | 22.2 ± 4.1 | 18.8 ± 4.3 | 18.7 ± 2.4 | 20.4 ± 2.5 | 19.4 ± 4.0 | 15.9 ± 3.0 | 20.8 ± 2.3 | 19.2 ± 2.6 | 16.7 ± 3.2 |