Table 4.

Univariate and multivariate analysis of prognostic factors of ETR and LTR in the purely local recurrence group.

Characteristic	ETR group			LTR group
	Univariate P-value HR (95% CI)		Multivariate P-value	Univariate P-value HR (95% CI)		Multivariate P-value
Age (years)	0.005		0.006	0.888		NS
≤46 years		Reference
>46 years		1.645 (1.153–2.346)			/
Gender	0.008		0.020	0.179		NS
Male		Reference
Female		0.589 (0.377–0.920)			/
Smoking status	0.293		NS	0.264		NS
Non-smoker
Smoker		/			/
Alcohol abuse	0.211		NS	0.043		NS
Non-drinker
Drinker		/			/
Tumor family history	0.883		NS	0.079		NS
No
Yes		/			/
Cranial nerve symptom	0.025		NS	0.836		NS
No
Yes		/			/
Baseline value of EBV-DNA	0.381		NS	0.015		0.017
≤2000					Reference
>2000		/			1.817 (1.115–2.962)
Histological type	0.257		NS	0.399		NS
WHO I/II
WHO III		/			/
T stage	0.110		NS	0.184		NS
1/2
3/4		/			/
N stage	0.074		NS	0.150		NS
0/1
2/3		/			/
TNM stage	0.069		NS	0.479		NS
I/II
III/IV					/
RT+/Chemo	0.316		NS	0.182		NS
RT alone
RT+Chemo		/			/