Table 9.
Univariate and multivariate analysis of post–recurrence prognostic factors of ELR and LLR in the locoregional recurrence group.
| Characteristic | ETR group | LTR group | ||||
|---|---|---|---|---|---|---|
| Univariate P-value HR (95% CI) | Multivariate P-value | Univariate P-value HR (95% CI) | Multivariate P-value | |||
| Age (years) | 0.069 | NS | 0.296 | NS | ||
| ≤46 years | ||||||
| >46 years | / | / | ||||
| Gender | 0.982 | NS | 0.076 | NS | ||
| Male | ||||||
| Female | / | / | ||||
| Smoking status | 0.284 | NS | 0.055 | NS | ||
| Non-smoker | ||||||
| Smoker | / | / | ||||
| Alcohol abuse | 0.255 | NS | 0.489 | NS | ||
| Non-drinker | ||||||
| Drinker | / | / | ||||
| Tumor family history | 0.144 | NS | 0.075 | NS | ||
| No | ||||||
| Yes | / | / | ||||
| Cranial nerve symptom | 0.050 | NS | 0.563 | NS | ||
| No | ||||||
| Yes | / | / | ||||
| Baseline value of EBV-DNA | 0.140 | NS | 0.963 | NS | ||
| ≤2,000 | ||||||
| >2,000 | / | / | ||||
| Histological type | 0.741 | NS | 0.056 | NS | ||
| WHO I/II | ||||||
| WHO III | / | / | ||||
| T stage | 0.387 | / | NS | 0.006 | 0.014 | |
| 1/2 | Reference | |||||
| 3/4 | 4.111 (1.337–12.635) | |||||
| N stage | 0.020 | 0.008 | 0.472 | / | NS | |
| 0/1 | Reference | |||||
| 2/3 | 2.216 (1.225–4.009) | |||||
| TNM stage | 0.252 | NS | 0.028 | NS | ||
| I/II | ||||||
| III/IV | / | / | ||||
| Post-recurrence treatment options | 0.002 | 0.007 | 0.000 | 0.000 | ||
| BST | Reference | Reference | ||||
| Salvage surgery | 0.238 (0.073–0.770) | 0.277 (0.028–1.749) | ||||
| Re-irradiation | 0.282 (0.090–0.885) | 0.565 (0.071–1.476) | ||||
| Chemotherapy | 0.666 (0.227–1.952) | 0.736 (0.343–1.284) | ||||