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. 2020 Jun 18;4:2398212820928647. doi: 10.1177/2398212820928647

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© The Author(s) 2020

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Figure 5. — AEP mismatch negativity phenotypes and NMDA mRNA expression. (a) Mismatch negativity stimulus. (b) Grand average ERP waveforms (shaded areas) after the saline or ketamine conditions in the in Ehmt1^fl/+ (n = 5) and Ehmt1^D6Cre/+ (n = 5), for the deviant (red) and standard (black) tone for each condition. (c1 and c2) Time-frequency plot of evoked power for the standard and deviant pulse in Ehmt1^fl/+ mice after saline injection. (c3 and c4) Time-frequency plot of evoked power for the standard and deviant pulse in Ehmt1^D6Cre/+ mice following saline injection. (d) N1 amplitude peak amplitude corresponding to each condition. (e1) Permutation test showing heat map of p-values for the difference of distribution between deviant tone maps of saline treated Ehmt1^fl/+ (c2) and Ehmt1^D6Cre/+ (c4). (e2) Permutation test showing heat map of p-values for the difference of distribution between deviant tone maps of ketamine treated Ehmt1^fl/+ (c2) and Ehmt1^D6Cre/+ (c4). (f) NMDA-R subunit mRNA expression in hippocampal samples (Ehmt1^fl/+ n = 4, Ehmt1^D6Cre/+ n = 8). Data shown are mean ± SEM. * represents main effect of GENOTYPE p < 0.05.