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. Author manuscript; available in PMC: 2020 Sep 9.
Published in final edited form as: J Med Chem. 2012 Oct 8;55(20):8671–8684. doi: 10.1021/jm3008773

Figure 1.

Figure 1.

Tdp1 in the repair of the stalled Top1–DNA complex: (A) noncovalent Top1–DNA complex; (B) transient Top1–DNA complex, which is trapped in the presence of a Top1 inhibitor; (C) the stalled Top1–DNA complex (cleavage complex) is repaired by Tdp1 via a transient Tdp1–DNA covalent intermediate; (D) Top1 is released and the Tdp1–DNA covalent intermediate resolved by hydrolysis; (E) 3′-phospho–DNA–end product.