Skip to main content
. Author manuscript; available in PMC: 2020 Sep 9.
Published in final edited form as: J Med Chem. 2012 Oct 8;55(20):8671–8684. doi: 10.1021/jm3008773

Table 2.

Impact of the Head Domain on Tdp1 Inhibitiona

compound Tdp1 IC50 (μM)
31 74
32 >333
33 >333
34 111–333
35 13 ± 3.0
36 >333
37 111–333
38 111–333
39 111–333
40 >111
41 >333
42 >111
43 2.6 ± 0.4
44 16 ± 8.8
45 27 ± 3.0
46 12 ± 2.2
a

IC50 values are expressed as mean ± SD from at least three independent experiments.