. Author manuscript; available in PMC: 2020 Sep 9.

Published in final edited form as: J Med Chem. 2012 Oct 8;55(20):8671–8684. doi: 10.1021/jm3008773

Table 3.

Aromatic Domain SAR of Thioxothiazolidinone Scaffold 22^a

Cpd	Tdp1 IC₅₀ (μM)	Cpd	Tdp1 IC₅₀ (μM)
43	2.6 ± 0.4	61	51 ± 25
47	5.8 ± 1.1	45	27 ± 3.0
48	4.1 ± 1.0	62	30 ± 12
49	7.1 ± 0.50	63	19 ± 6.4
50	0.87 ± 0.07	64	28 ± 7.6
51	39 ± 9.4	65	44
52	26	66	75 ± 29
53	34 ± 13	67	46 ± 15
54	11 ± 4.0	68	34 ± 7.8
55	48 ± 16	46	12 ± 2.2
44	16 ± 8.8	69	40 ± 11
56	15 ± 1.2	70	32
57	15 ± 4.7	71	111
58	7.8	72	20 ± 3.5
59	8.5	73	29 ± 6.0
60	6.7 ± 0.40	74	2.2 ± 0.5

IC₅₀ values are expressed as mean ± SD from at least three independent experiments.