Table 2.

DLTs in phase 1 dose escalation

Arm	Predose	177Lu-lilotomab dose (MBq/kg)	DLT	Disease
Index patient	Rituximab 250 mg/m2	10	Thrombocytopenia	FL
1	Lilotomab 40 mg	10	—	FL
		10	—	FL
		10	—	FL
		15	—	FL
		15	—	FL
		15	—	FL
		15	Thrombocytopenia, neutropenia	FL
		15	—	FL
		15	Hyponatremia	FL
		20	Neutropenia	FL
		20	Epistaxis	MCL
		20	Neutropenia	FL
2	No predose	10	—	FL
		15	Thrombocytopenia, neutropenia	FL
		15	Thrombocytopenia	FL
3	Rituximab 375 mg/m2	15	Thrombocytopenia, neutropenia	MZL
		15	—	FL
		15	—	MCL
4	Lilotomab 100 mg/m2	15	—	FL
		15	—	FL
		15	—	FL
		20	—	FL
		20	—	FL
		20	Hematuria with platelet count 40 × 109/L	FL
		20	—	MCL
		20	—	FL
		20	—	FL
		20	—	FL
5	Lilotomab 60 mg/m2	20	—	FL
		20	—	FL
		20	—	FL