Figure 4.

NEO2734 is more active than birabresib, CBP30, and NEO1132 in DLBCL cell lines. IC₅₀ and IC₉₀ values calculated for DLBCL cell lines exposed for 72 hours to the compounds. (A) IC₅₀ value comparison between NEO2734, NEO1132, birabresib, and CBP30. (B) IC₉₀ value comparison between NEO2734 and birabresib. (C) AUC comparison between NEO2734 and birabresib. Each point represents 1 cell line with the respective IC₅₀/IC₉₀/AUC. The line in the middle of the boxes represents the median IC₅₀/IC₉₀/AUC with 95% of CI. IC₉₀ values >20 μM were arbitrarily set as 30 μM. Statistics were calculated with the Mann-Whitney U test. *P < .05, **P < .01, ****P < .0001. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.