Fig. 1.

GREAT analysis identifies 8405 human genes associated with 35,074 neuro-regulatory human-specific single nucleotide changes (hsSNCs) identified in differentially accessible (DA) chromatin regions during human and chimpanzee brain development in cerebral organoids. a Patterns of genomic associations between neuro-regulatory hsSNCs and putative target genes defined at different single nearest gene maximum extensions. GREAT algorithm version 4.0.4. b A total of 1064 of all 35,074 SNCs (3%) are not associated with any genes in the human genome, while a total of 34,010 (97%) human-specific SNCs in DA regions appear associated with 8405 human genes. GREAT algorithm version 3.0.0