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. 2020 Sep 9;28(3-4):331–354. doi: 10.1007/s10577-020-09639-w

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© Springer Nature B.V. 2020

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 4 — SCARS-regulated genes associated with neuro-regulatory human-specific SNCs manifest prominent patterns of significant associations with physiological and pathological phenotypes of modern humans. Among all neuro-regulatory human-specific SNC-linked genes, 5389 SCARS-regulated genes were identified and segregated from the remaining 3016 non-SCARS-regulated hsSNC-linked genes (non-SCARS-regulated genes). These two categories of hsSNC-linked genes were subjected to gene set enrichment analyses to identify statistically significant associations with morphological features and physiological and pathological phenotypes of modern humans. Results of the analyses were separated into two sets (a and b) using a threshold of 250 significant records per database and plotted for visualization. a The results with less than 250 significant records, while the results with more than 250 significant records are reported in the b. c The summary of the results reflecting prominent contributions of SCARS-regulated genes to a global scale of significant associations of neuro-regulatory human-specific SNC-linked genes to morphological features and physiological and pathological phenotypes of modern humans.

Fig. 4 — SCARS-regulated genes associated with neuro-regulatory human-specific SNCs manifest prominent patterns of significant associations with physiological and pathological phenotypes of modern humans. Among all neuro-regulatory human-specific SNC-linked genes, 5389 SCARS-regulated genes were identified and segregated from the remaining 3016 non-SCARS-regulated hsSNC-linked genes (non-SCARS-regulated genes). These two categories of hsSNC-linked genes were subjected to gene set enrichment analyses to identify statistically significant associations with morphological features and physiological and pathological phenotypes of modern humans. Results of the analyses were separated into two sets (a and b) using a threshold of 250 significant records per database and plotted for visualization. a The results with less than 250 significant records, while the results with more than 250 significant records are reported in the b. c The summary of the results reflecting prominent contributions of SCARS-regulated genes to a global scale of significant associations of neuro-regulatory human-specific SNC-linked genes to morphological features and physiological and pathological phenotypes of modern humans.