Table 5.
Comparisons of impacts of 5389 SCARS-regulated genes and 3016 non-SCARS-regulated genes linked with human-specific neuro-regulatory SNCs on a global scale of significant associations to aging and diseases of modern humans
| Aging-associated gene expression changes | |||
| Aging upregulated genes | Number of significantly enriched records (n) | Percent | Enrichment ratio |
| All genes linked with human-specific neuro-regulatory SNCs (n = 8405) | 34 | ||
| SCARS-regulated hsSNC-linked genes (n = 5389) | 130 | 97.0 | 32.5 |
| Non-SCARS-regulated hsSNC-linked genes (n = 3016) | 4 | 3.0 | |
| Aging downregulated genes | Number of significantly enriched records (n) | Fold enrichment | |
| All genes linked with human-specific neuro-regulatory SNCs (n = 8405) | 67 | ||
| SCARS-regulated hsSNC-linked genes (n = 5389) | 155 | 98.7 | 77.5 |
| Non-SCARS-regulated hsSNC-linked genes (n = 3016) | 2 | 1.3 | |
| Disease-associated gene expression changes | |||
| Diseases GEO database (upregulated genes) | Number of significantly enriched records (n) | Fold enrichment | |
| All genes linked with human-specific neuro-regulatory SNCs (n = 8405) | 204 | ||
| SCARS-regulated hsSNC-linked genes (n = 5389) | 507 | 99.2 | 126.8 |
| Non-SCARS-regulated hsSNC-linked genes (n = 3016) | 4 | 0.8 | |
| Diseases GEO database (downregulated genes) | Number of significantly enriched records (n) | Fold enrichment | |
| All genes linked with human-specific neuro-regulatory SNCs (n = 8405) | 240 | ||
| SCARS-regulated hsSNC-linked genes (n = 5389) | 476 | 97.9 | 47.6 |
| Non-SCARS-regulated hsSNC-linked genes (n = 3016) | 10 | 2.1 | |
| DisGeNET database | Number of significantly enriched records (n) | Fold enrichment | |
| All genes linked with human-specific neuro-regulatory SNCs (n = 8405) | 1313 | ||
| SCARS-regulated hsSNC-linked genes (n = 5389) | 1126 | 98.5 | 66.2 |
| Non-SCARS-regulated hsSNC-linked genes (n = 3016) | 17 | 1.5 | |
Differential GSEA were carried out independently on 5389 SCARS-regulated and 3016 non-SCARS-regulated neuro-regulatory hsSNC-linked genes employing 29 genomic databases. Results were recorded and reported for comparisons of the numbers of significantly enriched records. Percent and enrichment ratio columns report metrics reflective of the relative contributions of SCARS-regulated and non-SCAS-regulated hsSNC-linked genes