Table 2.
mRNA Isoform Expression of Human SLC51A and SLC51B in Various Tissues and Cell Types from Healthy Individuals.
| SLC51A Level | SLC51B Level | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tissue / Cell Type | ENST 00000 296327 |
ENST 00000 415111 |
ENST 00000 416660 |
ENST 00000 428985 |
ENST 00000 442203 |
ENST 00000 471430 |
ENST 00000 472653 |
ENST 00000 475271 |
ENST 00000 475672 |
ENST 00000 476129 |
ENST 00000 479732 |
ENST 00000 484407 |
ENST 00000 492794 |
ENST 00000 496737 |
Average | Sum | ENST 00000 334287 |
| Adipose Tissue | 0.07 | 0.42 | 0.04 | 0.06 | 0.14 | 0.04 | 0.00 | 0.06 | 0.25 | 0.06 | 1.45 | 0.05 | 0.74 | 1.51 | 0.35 | 4.89 | 0.86 |
| Adrenal Gland | 3.40 | 0.66 | 0.68 | 0.43 | 0.34 | 1.02 | 0.41 | 0.00 | 1.03 | 0.28 | 2.13 | 5.66 | 1.38 | 1.86 | 1.38 | 19.29 | 1.32 |
| Appendix | 1.02 | 0.59 | 0.16 | 0.12 | 0.80 | 0.49 | 0.58 | 0.00 | 0.54 | 0.08 | 1.45 | 0.70 | 0.63 | 2.79 | 0.71 | 9.96 | 4.48 |
| Basophil | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.93 | 0.12 | 1.72 | 0.01 |
| Bone Marrow | 0.52 | 1.16 | 0.91 | 1.37 | 3.02 | 1.00 | 1.05 | 0.14 | 0.58 | 3.70 | 1.17 | 5.29 | 1.38 | 4.54 | 1.84 | 25.82 | 0.53 |
| Breast | 0.00 | 0.22 | 0.00 | 0.06 | 0.26 | 0.00 | 0.03 | 0.04 | 0.00 | 0.00 | 0.00 | 0.26 | 0.39 | 0.11 | 0.10 | 1.38 | 0.06 |
| Cerebral Cortex | 0.00 | 0.33 | 0.10 | 0.03 | 0.20 | 0.45 | 0.07 | 0.00 | 0.41 | 0.17 | 1.24 | 0.13 | 0.62 | 1.68 | 0.39 | 5.45 | 5.95 |
| Cervix, Uterine | 0.60 | 0.17 | 0.00 | 0.13 | 0.29 | 0.11 | 0.00 | 0.00 | 0.00 | 0.13 | 0.07 | 0.10 | 1.07 | 0.00 | 0.19 | 2.67 | 59.69 |
| Classical Monocyte | 0.00 | 0.04 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.01 | 0.06 | 0.01 | 0.31 | 0.00 | 0.08 | 0.33 | 0.08 | 1.06 | 0.00 |
| Colon | 9.30 | 0.37 | 0.02 | 0.24 | 0.31 | 0.66 | 0.87 | 0.09 | 0.35 | 0.27 | 0.67 | 3.73 | 5.63 | 0.61 | 1.65 | 23.14 | 40.73 |
| Duodenum | 28.07 | 0.60 | 0.11 | 0.58 | 1.65 | 3.51 | 3.11 | 0.00 | 1.22 | 1.82 | 1.78 | 7.61 | 7.44 | 3.38 | 4.35 | 60.87 | 85.37 |
| Endometrium | 0.04 | 0.53 | 0.00 | 0.04 | 0.29 | 0.00 | 0.02 | 0.02 | 0.22 | 0.00 | 1.22 | 0.22 | 0.62 | 1.75 | 0.36 | 4.97 | 5.52 |
| Eosinophil | 0.22 | 0.01 | 0.00 | 0.00 | 0.33 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.34 | 0.24 | 0.00 | 0.71 | 0.13 | 1.87 | 0.00 |
| Epididymis | 0.97 | 0.00 | 0.00 | 0.00 | 0.41 | 0.66 | 0.30 | 0.00 | 0.00 | 0.00 | 0.30 | 1.58 | 0.00 | 0.14 | 0.31 | 4.37 | 0.39 |
| Esophagus | 0.00 | 0.61 | 0.00 | 0.00 | 0.13 | 0.27 | 0.03 | 0.10 | 0.49 | 0.00 | 2.44 | 0.00 | 1.01 | 2.16 | 0.52 | 7.23 | 2.71 |
| Fallopian Tube | 2.08 | 0.30 | 0.00 | 0.16 | 0.32 | 0.25 | 0.25 | 0.00 | 0.25 | 0.06 | 0.59 | 0.95 | 0.73 | 0.37 | 0.45 | 6.30 | 6.01 |
| Gallbladder | 0.13 | 0.84 | 0.08 | 0.00 | 0.25 | 0.18 | 0.00 | 0.02 | 0.44 | 0.08 | 1.95 | 0.10 | 0.34 | 3.47 | 0.56 | 7.88 | 4.33 |
| gdTCR | 0.00 | 0.01 | 0.00 | 0.00 | 0.34 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.62 | 0.00 | 0.22 | 0.56 | 0.13 | 1.87 | 0.03 |
| Heart Muscle | 0.00 | 0.09 | 0.11 | 0.00 | 0.10 | 0.07 | 0.02 | 0.00 | 0.23 | 0.11 | 1.78 | 0.04 | 0.57 | 0.85 | 0.28 | 3.98 | 1.66 |
| Intermediate Monocyte | 0.00 | 0.02 | 0.06 | 0.00 | 0.16 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.27 | 0.00 | 0.07 | 0.28 | 0.06 | 0.91 | 0.00 |
| Kidney | 4.42 | 0.71 | 0.04 | 0.21 | 0.17 | 0.37 | 0.08 | 0.40 | 0.51 | 0.11 | 0.85 | 3.28 | 3.65 | 0.59 | 1.10 | 15.37 | 19.35 |
| Liver (Fetal) | Detected* | Detected* | |||||||||||||||
| Liver | 31.95 | 1.48 | 0.00 | 1.42 | 0.75 | 2.96 | 1.73 | 0.88 | 0.98 | 0.45 | 0.56 | 18.97 | 24.38 | 0.40 | 6.21 | 86.90 | 0.93 |
| Lung | 0.20 | 0.36 | 0.16 | 0.03 | 0.24 | 0.26 | 0.13 | 0.03 | 0.22 | 0.10 | 1.22 | 0.32 | 0.30 | 1.38 | 0.35 | 4.95 | 9.37 |
| Lymph Node | 0.00 | 0.70 | 0.04 | 0.01 | 0.35 | 0.08 | 0.00 | 0.03 | 0.16 | 0.11 | 1.18 | 0.46 | 0.65 | 3.37 | 0.51 | 7.14 | 0.75 |
| MAIT T-cell | 0.00 | 0.01 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.43 | 0.00 | 0.02 | 0.20 | 0.07 | 0.93 | 0.03 |
| Memory B-cell | 0.00 | 0.01 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.29 | 0.00 | 0.12 | 0.30 | 0.07 | 0.98 | 0.00 |
| Memory CD4 T-cell | 0.00 | 0.01 | 0.02 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.13 | 0.00 | 0.48 | 0.00 | 0.16 | 0.39 | 0.10 | 1.39 | 0.02 |
| Memory CD8 T-cell | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.05 | 0.68 | 0.02 |
| Myeloid DC | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.29 | 0.00 | 0.12 | 0.34 | 0.06 | 0.90 | 0.01 |
| Naive B-cell | 0.00 | 0.03 | 0.00 | 0.00 | 0.46 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.34 | 0.00 | 0.14 | 0.36 | 0.10 | 1.40 | 0.00 |
| Naive CD4 T-cell | 0.00 | 0.02 | 0.00 | 0.00 | 0.30 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.03 | 0.02 | 0.29 | 0.08 | 1.10 | 0.01 |
| Naive CD8 T-cell | 0.00 | 0.08 | 0.01 | 0.00 | 0.31 | 0.00 | 0.00 | 0.00 | 0.24 | 0.01 | 0.53 | 0.00 | 0.28 | 0.45 | 0.14 | 1.91 | 0.02 |
| Neutrophil | 0.00 | 0.03 | 0.14 | 0.00 | 1.24 | 0.00 | 0.01 | 0.00 | 0.07 | 0.00 | 0.73 | 0.00 | 0.07 | 0.64 | 0.21 | 2.93 | 0.03 |
| NK-cell | 0.00 | 0.09 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.43 | 0.00 | 0.00 | 0.51 | 0.11 | 1.59 | 0.00 |
| Non-Classical Monocyte | 0.00 | 0.05 | 0.02 | 0.00 | 0.19 | 0.02 | 0.00 | 0.00 | 0.08 | 0.01 | 0.57 | 0.00 | 0.11 | 0.57 | 0.12 | 1.63 | 0.01 |
| Ovary | 0.07 | 0.89 | 0.10 | 0.00 | 0.11 | 0.39 | 0.00 | 0.00 | 0.38 | 0.11 | 1.00 | 6.21 | 0.35 | 0.76 | 0.74 | 10.36 | 1.52 |
| Pancreas | 0.00 | 0.00 | 0.00 | 0.01 | 0.11 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.08 | 0.06 | 0.23 | 0.32 | 0.06 | 0.86 | 0.05 |
| Parathyroid Gland | 3.18 | 1.94 | 0.00 | 0.00 | 0.00 | 3.39 | 0.56 | 0.00 | 0.53 | 0.00 | 0.11 | 3.51 | 1.94 | 0.21 | 1.10 | 15.37 | 0.00 |
| Pituitary Gland | Detected* | Detected* | |||||||||||||||
| Placenta | 0.01 | 0.34 | 0.00 | 0.00 | 0.25 | 0.04 | 0.02 | 0.06 | 0.20 | 0.02 | 0.88 | 0.09 | 0.29 | 0.73 | 0.21 | 2.93 | 1.00 |
| Plasmacytoid DC | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.28 | 0.00 | 0.08 | 0.36 | 0.08 | 1.14 | 0.00 |
| Prostate | 0.16 | 0.41 | 0.00 | 0.05 | 0.37 | 0.13 | 0.05 | 0.05 | 0.35 | 0.33 | 0.87 | 0.16 | 0.75 | 0.94 | 0.33 | 4.62 | 2.94 |
| Rectum | 0.53 | 0.07 | 0.00 | 0.20 | 0.11 | 0.05 | 0.09 | 0.00 | 0.00 | 0.12 | 0.09 | 0.60 | 0.66 | 0.10 | 0.19 | 2.61 | 31.41 |
| Salivary Gland | 0.21 | 0.30 | 0.00 | 0.04 | 0.08 | 0.14 | 0.01 | 0.04 | 0.06 | 0.19 | 0.44 | 0.06 | 0.18 | 0.57 | 0.17 | 2.33 | 0.47 |
| Seminal Vesicle | 0.06 | 0.07 | 0.00 | 0.00 | 0.23 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.06 | 0.03 | 0.04 | 0.53 | 0.94 |
| Skeletal Muscle | 0.03 | 0.21 | 0.38 | 0.00 | 0.40 | 0.15 | 0.06 | 0.00 | 0.36 | 0.29 | 1.20 | 0.24 | 0.33 | 0.83 | 0.32 | 4.50 | 0.38 |
| Skin | 0.03 | 1.35 | 0.00 | 0.00 | 0.59 | 0.26 | 0.03 | 0.16 | 1.00 | 0.08 | 4.27 | 0.14 | 1.86 | 6.55 | 1.17 | 16.32 | 1.03 |
| Small Intestine | 65.43 | 1.49 | 0.15 | 4.22 | 4.28 | 6.97 | 8.62 | 0.60 | 1.53 | 3.79 | 2.11 | 20.32 | 16.80 | 5.20 | 10.11 | 141.52 | 118.33 |
| Smooth Muscle | 0.31 | 0.04 | 0.00 | 0.12 | 0.21 | 0.10 | 0.21 | 0.00 | 0.00 | 0.02 | 0.00 | 0.58 | 0.35 | 0.00 | 0.14 | 1.94 | 2.56 |
| Spleen | 0.00 | 0.93 | 0.04 | 0.00 | 0.42 | 0.00 | 0.04 | 0.00 | 0.30 | 0.29 | 1.28 | 0.03 | 0.44 | 3.13 | 0.49 | 6.89 | 1.20 |
| Stomach | 0.15 | 0.32 | 0.03 | 0.00 | 0.18 | 0.00 | 0.00 | 0.00 | 0.16 | 0.05 | 0.91 | 0.03 | 0.18 | 1.33 | 0.24 | 3.35 | 0.80 |
| T-reg | 0.00 | 0.02 | 0.00 | 0.00 | 0.34 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.14 | 0.00 | 0.07 | 0.24 | 0.06 | 0.85 | 0.00 |
| Testis | 1.23 | 1.02 | 2.67 | 0.75 | 1.18 | 1.00 | 0.44 | 0.48 | 2.66 | 0.24 | 1.63 | 12.32 | 6.06 | 1.75 | 2.39 | 33.44 | 13.12 |
| Thyroid Gland | 0.51 | 1.03 | 0.00 | 0.00 | 0.44 | 0.13 | 0.20 | 0.12 | 0.17 | 0.32 | 1.48 | 0.57 | 0.70 | 1.42 | 0.51 | 7.10 | 1.16 |
| Tonsil | 0.22 | 0.22 | 0.00 | 0.04 | 0.07 | 0.13 | 0.02 | 0.12 | 0.06 | 0.00 | 0.06 | 1.01 | 0.26 | 0.12 | 0.17 | 2.35 | 0.06 |
| Total PBMC | 0.00 | 0.01 | 0.00 | 0.00 | 0.07 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.13 | 0.00 | 0.06 | 0.08 | 0.03 | 0.38 | 0.01 |
| Urinary Bladder | 0.04 | 0.37 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.78 | 0.14 | 0.00 | 1.43 | 0.23 | 3.23 | 3.19 |
| Average | 2.77 | 0.39 | 0.11 | 0.18 | 0.46 | 0.45 | 0.34 | 0.06 | 0.30 | 0.24 | 0.83 | 1.71 | 1.51 | 1.14 | 0.75 | 10.50 | 7.69 |
Data on transcript levels were obtained from The Human Protein Atlas version 19 and Ensembl version 92.38, and were determined using next-generation sequencing-based RNA-sequencing. Values are presented as transcripts per million. A color scale was applied to each column separately, with green and red denoting the highest and lowest levels of expression, respectively.
*
Some tissues were not analyzed in The Human Protein Atlas for SLC51A and SLC51B mRNA levels, but positive levels were detected in another study (Seward, et al., 2003). According to ensembl.org, only ENST00000296327 (340 amino acids), ENST00000415111 (23 amino acids), ENST00000416660 (66 amino acids) and ENST00000428985 (212 amino acids) are protein-coding SLC51A transcripts. gdTCR, gamma delta T cell; DC, dendritic cell; MAIT T-cell, mucosal associated invariant T-cell; NK-cell, natural killer cell; T-reg, regulatory T cell; PBMC, peripheral blood mononuclear cell.