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. 2020 Aug 7;219(9):e202005126. doi: 10.1083/jcb.202005126

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© 2020 Chen and Schmid

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Figure 3. — Potential mechanisms of curvature generation/stabilization at CCPs. Left to right: Scaffolding effect via imprinting the curved clathrin coats; scaffolding effect via imprinting the intrinsic shape of dimeric BAR domains (e.g., in Fcho1/2, endophilin, amphiphysin, and SNX9); wedging effect via hydrophobic insertion of amphipathic helices (e.g., in epsin1, AP180/CALM, endophilin, and amphiphysin); and crowding effect via steric force generated by the accumulation of proteins encoding large intrinsically disorderd domains (e.g., in epsin1, Fcho1/2, AP180/CALM, and amphiphysin).