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. 2020 Jul 17;219(9):e202001120. doi: 10.1083/jcb.202001120

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© 2020 Chiusa et al.

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Figure 5. — Increased glomerular collagen IV deposition in Itgα1KO mice and human fibrotic kidneys. (A and C) Paraffin kidney sections from WT and Itgα1KO mice (A) as well as from healthy controls or subjects with focal segmental glomerulosclerosis (FSGS) or diabetic nephropathy (DN; B, two subjects per group) were stained with anti-collagen IV α1 and α2 chain antibody. Increased glomerular collagen IV staining is evident in the glomeruli of Itgα1KO mice and in the glomeruli of kidneys from subjects with FSGS or DN compared with healthy controls. (B) The amount of glomerular collagen IV in A was quantified using ImageJ and expressed as percentage collagen IV levels/glomerulus. Circles represent single glomeruli (44 WT and 72 Itgα1KO) and bars represent mean ± SD (n = 4 WT and 6 Itgα1KO mice). Two-tailed t test was used for statistical analysis.