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Schematic depiction of FUS regulation by the Itgα1β1/EGFR axis. (A) In healthy mesangial cells, activation of Itgα1β1 negatively regulates EGFR activation, thus reducing EGFR-mediated FUS phosphorylation, FUS nuclear translocation, and transcription of the collagen IV α2 chain. (B) In cells lacking Itgα1β1, increased EGFR activation results in enhanced FUS phosphorylation and FUS-mediated collagen transcription.
