Table 2. Conserved features in SARS-CoV-2 and SARS-CoV interactomes.
| HEK293 (Gordon et al., 2020) | A549 (Stukalov et al., 2020) | ||
|---|---|---|---|
| Secretory pathway components | SARS-CoV-2 | SARS-CoV | SARS-CoV-2 |
| ACSL3 | nsp7 | - | - |
| ALG11 | nsp4 | orf7b | orf7b |
| ALG5 | orf3a | orf7b | orf7b |
| ALG8 | orf9c | orf7b | orf7b |
| CDK5RAP2 | nsp13 | - | - |
| CHPF | orf8 | - | - |
| CHPF2 | orf8 | - | - |
| CLCC1 | orf3a | orf3a | orf3 |
| COLGALT1 | nsp1 | - | - |
| COQ8B | M | M | M |
| CYB5R3 | nsp7 | - | - |
| EDEM3 | orf8 | - | - |
| ERC1 | nsp13 | - | - |
| ERGIC1 | nsp10 | - | - |
| ERLEC1 | orf8 | orf8 | orf8 |
| ERMP1 | orf9c | orf7b | orf7b |
| ERO1B | orf8 | - | - |
| ERp44 | orf8 | - | - |
| FKBP10 | orf8 | - | - |
| FKBP7 | orf8 | - | - |
| FOXRED2 | orf8 | - | - |
| GCC1 | nsp13 | - | - |
| GCC2 | nsp13 | - | - |
| GGCX | nsp13 | - | - |
| GIGYF2 | nsp2 | - | - |
| GOLGA2 | nsp13 | - | - |
| GOLGA3 | nsp13 | - | - |
| GOLGA7 | S | - | S |
| GOLGB1 | nsp13 | orf7b | orf7b |
| GORASP1 | nsp13 | - | - |
| GPAA1 | orf9c | nsp6 | nsp6 |
| HMOX1 | orf3a | - | - |
| HS2ST1 | nsp7 | - | - |
| HYOU1 | orf8 | - | - |
| LMAN2 | nsp7 | orf7b | orf7b |
| MOGS | nsp7 | - | - |
| NDFIP2 | orf9c | orf3a | orf3 |
| NPC2 | orf8 | - | - |
| NUP210 | nsp4 | - | - |
| OS9 | orf8 | orf8 | orf8 |
| PCSK6 | orf8 | - | - |
| PDE4DIP | nsp13 | N | N |
| PIGO | orf9c | orf7b | orf7b |
| PIGS | orf9c | nsp6 | nsp6 |
| PLD3 | orf8 | orf7b | orf7b |
| PLEKHF2 | orf8 | - | - |
| PMPCA | M | orf8b | - |
| POFUT1 | orf8 | - | - |
| POGLUT2 | orf8 | - | - |
| POGLUT3 | orf8 | - | - |
| POR | nsp2 | - | - |
| PTGES2 | nsp7 | - | - |
| RAB10 | nsp7 | - | - |
| RAB14 | nsp7 | orfa | orf3 |
| RAB1A | nsp7 | orf3a | orf3 |
| RAB2A | nsp7 | orf3a | orf3 |
| RAB8A | nsp7 | orf3a | orf3 |
| RAP1GDS1 | nsp2 | nsp2 | nsp2 |
| REEP5 | M | orf8 | orf7b |
| REEP6 | M | - | - |
| RETREG3 | orf9c | orf7b | orf7b |
| RNF41 | nsp15 | - | - |
| RTN4 | M | - | M |
| SCAP | orf9c | orf7b | orf7b |
| SDF2 | orf8 | orf8 | - |
| SELENOS | nsp7 | orf7b | orf7b |
| SIGMAR1 | nsp6 | - | - |
| SIL1 | orf8 | - | - |
| SLC27A2 | nsp2 | - | - |
| SLC30A6 | orf9c | - | - |
| SLC30A7 | M | - | - |
| SLC30A9 | M | - | - |
| SRP72 | nsp8 | - | - |
| TAPT1 | orf9c | orf7b | orf7b |
| TM2D3 | orf8 | - | - |
| TMED5 | orf9c | - | - |
| TMEM97/SIGMAR2 | orf9c | orf3a | orf3 |
| TOR1A | orf8 | - | orf3 |
| TRIM59 | orf3a | orf7b | orf7b |
| UBXN8 | orf9c | - | - |
| UGGT2 | orf8 | orf8 | orf8 |
| WFS1 | orf9c | nsp6 | nsp6 |
| YIF1A | M | - | - |
| ZDHHC5 | S | S | S |
Proteins listed in Table 1 were matched with human protein–protein interactions obtained in A549 cells expressing SARS-CoV or SARS-CoV-2 proteins (Stukalov et al., 2020). The comparison highlights cell type– and virus-specific differences within an overall similarity of the interactome.