Table 3. Potential perturbagens of the interactions between SARS-CoV-2 and proteins of the early secretory pathway.

Rank	Cell line	Perturbagen	Dose (μm)	Duration (h)	Score	Perturbed genes
1	MCF7	Epicatechin monogallate	10.0	6	1,000	GOLGB1, PDE4DIP, TOR1A
2	PC3	s1154	10.0	6	0.923	HMOX1, PDE4DIP
3	PC3	BRD-A82197375	10.0	6	0.738	TOR1A
4	A375	ganciclovir	10.0	6	0.600	GOLGB1, HMOX1
5	MCF7	estrone	10.0	6	0.554	HMOX1, PDE4DIP
6	A549	GDC-0879	3.33	24	0.431	HMOX1
7	VCAP	sertaconazole_nitrate	10.0	24	0.323	PDE4DIP
8	BT20	radicicol	1.11	3	0.292	HMOX1, HYOU1
9	VCAP	BRD-A16581344	10.0	24	0.231	HYOU1, PDE4DIP
10	A549	SB-216763	10	24	0.231	PDE4DIP
11	VCAP	cetirizine_dihydrochloride	10.0	6	0.231	HYOU1, PDE4DIP
12	HCC515	bcl-2_inhibitor	10.0	24	0.169	GOLGB1, HMOX1, TAPT1
13	HA1E	betamethasone	10.0	24	0.169	GOLGB1, HMOX1, PDE4DIP
14	MCF7	t0513-6584	10.0	6	0.154	TOR1A
15	MCF7	e6_berbamine	10.0	6	0.154	PDE4DIP
16	A549	dabrafenib	0.12	24	0.154	HMOX1
17	THP1	BRD-K31342827	12.12	6	0.154	HMOX1, HYOU1, TAPT1
18	A375	BRD-K19410523	10.0	6	0.154	HMOX1, PDE4DIP
19	MCF10A	NVP-AUY922	10	3	0.138	HMOX1, HYOU1, WFS1
20	PC3	mls-0435429	10.0	6	0.123	HMOX1, PDE4DIP
21	BT20	radicicol	3.33	3	0.123	HMOX1, HYOU1
22	HA1E	np-010914	10.0	6	0.108	ERMP1, HYOU1, PDE4DIP
23	HME1	geldanamycin	3.33	3	0.108	HMOX1, HYOU1, PDE4DIP
24	MCF7	metergoline	10.0	24	0.108	TOR1A
25	A549	HY-11007	10	24	0.108	TOR1A
26	MCF7	BRD-K05593511	10.0	6	0.077	GOLGB1, PDE4DIP

The table highlights compounds, ordered according to their statistical scoring, which perturb gene subsets of the input signature (last column), when administered in the indicated cell line. The input gene signature has been derived from the BioInfoMiner analysis, using the MGIMP ontology, for the CoV-2 secretome (87 protein interactions).