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Low-toxic dose of shikonin suppresses LPS-induced endotoxin shock and TNF-α production in mice. (A) Within 72 h of initial LPS and D-galactosamine administration, the survival of mice was recorded every 4 h. (B) After 8 h of LPS injection, serum samples were collected from tail vein and the levels of TNF-α were tested by ELISA. *P<0.05 vs. control group; #P<0.05 vs. D-galactosamine and LPS group. C, control; LPS, lipopolysaccharide; TNF-α, tumor necrosis factor α.
