Table V.
Univariate and multivariate analysis of prognostic factors for recurrence-free survival.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Prognostic factor | HR (95%CI) | P-value | HR (95%CI) | P-value |
| MUC1 (≥0.056 vs. <0.056, ratio to GAPDH) | 2.187 (1.171-4.083) | 0.014 | 2.552 (1.294-5.032) | 0.007 |
| Bile duct invasion (yes vs. No) | 2.445 (1.022-5.851) | 0.045 | 3.979 (1.449-10.928) | 0.007 |
| Tumor diameter (>5 cm vs. ≤5 cm) | 1.977 (1.026-3.810) | 0.042 | 1.130 (0.509-2.510) | 0.764 |
| T stage (T2-4 vs. T1) | 1.468 (1.039-2.073) | 0.029 | 1.403 (0.931-2.115) | 0.106 |
| LN metastasis (yes vs. no) | 2.449 (1.256-4.776) | 0.009 | 2.053 (1.042-4.046) | 0.038 |
| Surrounding tissue invasion (yes vs. no) | 2.045 (0.628-6.656) | 0.235 | ||
| CEA (≥20 ng/ml vs. <20 ng/ml) | 1.108 (10.567-2.167) | 0.764 | ||
| CA-19-9 (≥37 ng/ml vs. <37 ng/ml) | 0.828 (0.452-1.516) | 0.540 | ||
| Differentiation (poor vs. well) | 1.930 (0.940-3.960 | 0.073 | ||
| Tumor number (solitary vs. multiple) | 1.504 (0.798-2.836) | 0.207 | ||
| Nerve invasion (yes vs. no) | 2.217 (0.679-7.239) | 0.187 | ||
| Vascular invasion (yes vs. no) | 0.971 (0.488-1.933) | 0.933 | ||
LN, lymph node; HR, hazard ratio; CA, cancer antigen.