Table 2.
Fatty acid analysis of plasma phospholipid fraction of experimental animals treated with alloxan to induce type 1 diabetes mellitus and their treatment with AA
| Fatty acid | Untreated control | Alloxan | AA only | Pre-AA + alloxan |
|---|---|---|---|---|
| MA 14:0 | 1.03 ± 0.07 | 3.54 ± 0.05a | 1.02 ± 0.16 | 1.36 ± 0.23b |
| PA 16:0 | 23.09 ± 0.6 | 29.3 ± 0.7a | 22.9 ± 0.5b | 23.1 ± 0.62b |
| POA 16:1 | 21.57 ± 1.48 | 29.4 ± 2.1a | 17.9 ± 0.7b | 16.4 ± 2.01b |
| SA 18:0 | 14.0 ± 1.2 | 15.24 ± 1.63 | 18.36 ± 2.16 | 19.57 ± 2.15 |
| OA 18:1 n-9 | 9.54 ± 0.46 | 6.3 ± 0.056a | 10.77 ± 0.38b | 11.8 ± 0.58a,b |
| LA 18:2 n-6 | 21.28 ± 0.8 | 11.74 ± 0.63a | 20.66 ± 1.3b | 21.72 ± 1.16b |
| GLA 18:3 n-6 | 1.28 ± 0.092 | 0.61 ± 0.049a | 1.7 ± 0.33b | 1.48 ± 0.22b |
| DGLA 20:3 n-6 | 1.49 ± 0.14 | 0.49 ± 0.053a | 1.45 ± 0.22b | 0.84 ± 0.16a |
| AA 20:4 n-6 | 0.96 ± 0.07 | 0.52 ± 0.04a | 1.54 ± 0.07a,b | 1.22 ± 1.07a,b |
| ALA 18:3 n-3 | 2.56 ± 0.16 | 1.8 ± 0.06 | 2.46 ± 0.08 | 1.97 ± 0.13 |
| EPA 20:5 n-3 | 0.35 ± 0.03 | 0.44 ± 0.04 | 0.3 ± 0.03 | 0.47 ± 0.08 |
| DHA 22:6 n-3 | 0.86 ± 0.07 | 1.39 ± 0.61a | 0.85 ± 0.07b | 0.77 ± 0.06b |
All values are expressed as mean ± SE (n = 10).
ap <0.05 compared to untreated control; bp <0.05 compared to alloxan group.
It is evident from this data that in alloxan treated Wistar animals there is a significant decrease in the plasma levels of LA, GLA, DGLA and AA that were restored to normal in alloxan + AA treated animals. There were no significant alterations in n-3 fatty acids (ALA, EPA) except that DHA was significantly increased in alloxan treated animals that was restored to normal in alloxan + AA treated animals. This data is taken from ref. (42).