Fig. 1.

Biosynthesis of phosphatidylcholine and phosphatidylinositol. Supplementation of inositol has been related to an improved production of phosphatidylinositol, being it the precursor. At the same time, inositol supplementation has been related to an increased production of phosphatidylcholine by modulation of CTP-phosphatidylcholine-cytidylyltransferase regulation with increased activity. CTP-phosphatidylcholine-cytidylyltransferase enzyme is the rate-limiting and regulated step in the CDP-choline pathway for the synthesis of phosphatidylcholine, and it is primarily regulated by multiple post-transcriptional mechanisms that improve the function by stabilizing the enzyme and favoring the translocation at the endoplasmic reticulum (ER) membrane.