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Phylogenetic relationships among invertebrate and vertebrate Crb proteins. A, Schematics of the structures of zebrafish Crb proteins. The coding exons are numbered from the 5′ end to the 3′ end. The antigenic region (amino acids 952–1258) for making anti-Crb1 antibody is underlined. B–D, The phylogenetic trees of the Crb proteins of 14 different species, generated by using full-length (B), extracellular (C), and intracellular amino acid sequences (D).
