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. 2020 Sep 9;40(37):7091–7104. doi: 10.1523/JNEUROSCI.2892-19.2020

Figure 3.

Figure 3.

Direct reticulospinal excitation of forelimb motor neurons is reduced in EphA4 knock-out mice. A, Samples of EPSPs evoked by stimulation of ipsilateral and contralateral MLF in forelimb motor neurons in wild-type (black), EphA4+/− (blue), and EphA4−/− (red) mice. IC, intracellular recordings; EC, extracellular recordings (gray lines); CDP, cord dorsum potential. 80 µA × 3, stimulation intensity with a train of 3 stimuli at 80 µA. B, Comparison of proportions of monosynaptic EPSPs in three groups of mice. χ2 test: ipsilateral (ipsi), X2(2, n = 109) = 6.4, p = 0.04; contralateral (contra), χ2(2, n = 113) = 13.6, p = 0.001. C, A transverse section shows ipsilateral and contralateral MLF and Pyr tracks for electrical stimulation. D, Comparison of peak amplitude of monosynaptic EPSPs evoked by stimulation of iMLF and coMLF in same MNs. E, Segmental latencies of EPSPs and IPSPs in each group. Empty triangle shows the latency of the direct volley. F, Summation of monosynaptic EPSPs evoked by stimulation of iMLF and coMLF in a same EphA4−/− MN suggested that there was no spreading effect with the intensity of 80 μA. Red lines show the average of three to five sweeps of EPSPs (black lines).