Figure 5.

ORs responsive to 1-pentanethiol in vivo. A, In mice, 58 ORs respond to headspace air above a solution of 25% 1-pentanethiol. Delta is the 1-pentanethiol response relative to the clean air control response. FDR values capped at 10⁻¹⁰. B, The distribution of responses, measured as the fold difference (FD) enrichment of receptor mRNAs in samples of active OSNs compared with inactive OSNs, identifies responses specific to 1-pentanethiol versus the clean air control. C, The responsive ORs are distributed in several clusters across the Class II portion of the OR sequence distance tree. D, Of the responsive ORs, nine are also responsive to cigarette smoke (blue squares). E, Clustering MOR families via similarity in family size and proportion of ORs responsive to 1-pentanethiol. Only a few OR families contain large fractions of responsive ORs. Only OR families containing responsive ORs are shown. Circle size reflects family size.