Fig. 8.
Illustration of the feasibility of a 7T QSM clinical study. χ (A) and R2* (B) for four ROIs (Substantia Nigra, SN; Caudate Nucleus, CN; Putamen, Pu; Globus Pallidus, GP) from healthy volunteer (HV) and synthetic “patient” (PT) data for which AVlit and SDlit were obtained from Langkammer et al. (2016) and SDb were calculated from data of the current study. AVlit values for R2* were linearly scaled to 7T according to Yao et al. (2007). Blue bars show the AVlit ± SDlit and green bars the AVlit ± SDb. Statistical differences between HV and PT obtained from Langkammer et al. (2016) are also shown. For each ROI, the sample size that would have been needed to give a significant effect was calculated from the group means, AVlit, and the SDb per ROI and is shown in circles. Multi-echo χ-maps were calculated with data from all eight echoes.