Table 1.
Important pathways regulated by QFPDD's putative targets.
| Database | Pathway Class | Pathway/superpathway | Targets | Total genes | FDR |
|---|---|---|---|---|---|
| Reactome | Cell growth and death | Apoptosis | 20 | 162 | 9.02E-06 |
| KEGG | Cell growth and death | Necroptosis | 20 | 155 | 3.49E-07 |
| KEGG | Cell growth and death | Autophagy - animal | 21 | 125 | 3.87E-09 |
| Reactome | Immune system | Signaling by Interleukins | 90 | 439 | 3.79E-39 |
| Reactome | Immune system | Toll-like Receptor Cascades | 32 | 151 | 6.07E-14 |
| KEGG | Immune system | NOD-like receptor signaling pathway | 27 | 166 | 4.18E-11 |
| KEGG | Immune system | RIG-I-like receptor signaling pathway | 13 | 70 | 1.41E-06 |
| Reactome | Hemostasis | 60 | 601 | 1.38E-12 | |
| Reactome | Metabolism | Biological oxidations | 37 | 214 | 9.23E-14 |
| Reactome | Metabolism | Arachidonic acid metabolism | 20 | 59 | 7.34E-12 |
| KEGG | Metabolism | Steroid hormone biosynthesis | 15 | 58 | 5.97E-09 |
| KEGG | Signal transduction | cAMP signaling pathway | 36 | 195 | 1.23E-15 |
| KEGG | Signal transduction | TNF signaling pathway | 27 | 108 | 1.28E-14 |
| KEGG | Signal transduction | HIF-1 signaling pathway | 24 | 98 | 5.38E-13 |
| KEGG | Signal transduction | NF-kappa B signaling pathway | 20 | 93 | 2.62E-10 |
| KEGG | Signal transduction | Calcium signaling pathway | 20 | 179 | 2.46E-06 |
| KEGG | Environmental adaptation | Thermogenesis | 21 | 228 | 1.94E-05 |
| KEGG | Digestive system | Bile secretion | 29 | 71 | 6.28E-20 |
| KEGG | Digestive system | Salivary secretion | 17 | 86 | 1.54E-08 |
| KEGG | Digestive system | Gastric acid secretion | 15 | 72 | 6.11E-08 |
| Reactome | Nervous system | Transmission across Chemical Synapses | 43 | 218 | 8.86E-18 |
| KEGG | Sensory system | Inflammatory mediator regulation of TRP channels | 17 | 92 | 3.61E-08 |
| KEGG | Sensory system | Taste transduction | 13 | 81 | 5.40E-06 |
| KEGG | Circulatory system | Adrenergic signaling in cardiomyocytes | 26 | 139 | 7.74E-12 |