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. Author manuscript; available in PMC: 2021 Sep 3.
Published in final edited form as: Cell. 2020 Sep 3;182(5):1198–1213.e14. doi: 10.1016/j.cell.2020.06.045

Figure 7.

Figure 7.

Selective sweep and association with platelet count at the IL6 locus in East Asians. The grey rectangle highlights a genomic region upstream of IL6 that is strongly associated with platelet (PLT) count. This association signal is driven by results from East Asians (EAS), and is absent from other populations, including European- (EUR) and African-ancestry (AFR) individuals (green). The region overlaps several selective sweeps detected in EAS from the 1000 Genomes Project (Chinese Dai in Xishuangbanna (CDX), Southern Han Chinese (CHS), Japanese in Tokyo (JPT)). In orange, we provide standardized population branch site (stdPBS) metrics in EUR and EAS, indicative of allele frequency differentiation at this locus between these two populations. Coordinates are chr7:22–23.5Mb (hg19). See also Figure S7 and Table S7A–C.