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. 2020 Jul 9;9(1):1785738. doi: 10.1080/20013078.2020.1785738

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Model: Sja-miR-71a in S. japonicum egg-derived EVs suppresses liver fibrosis in schistosomiasis by targeting semaphorin 4D. S. japonicum egg-derived EVs can inhibit the activation of HSCs, and this inhibition is mediated via the high expression of Sja-miR-71a. Sja-miR-71a attenuates the liver fibrosis in S. japonicum infection by Sema4D/TGF-β1 axis and Sema4D/IL-13 axis. In addition, Sja-miR-71a suppression of liver fibrosis is partly mediated by regulating Th1, Th2, Th17 and Treg balance via inhibiting Sema4D.