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. 2020 Aug 26;9(1):1809765. doi: 10.1080/20013078.2020.1809765

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Diagnostic values for the EV detection assays in CRC samples.

Plasma from healthy control patients (n = 46) and cancer patients (adenoma, n = 51, and CRC, n= 163) was measured with the CD9-CD63 (A) and Epcam-CD63 (B) assays. (C) ROC curves obtained with the CD9-CD63 SiMoa assay, the Epcam-CD63 SiMoa assay and the traditional serological markers CEA and CA125 are shown for colorectal cancer versus healthy controls. The CD9-CD63 assay shows the best AUC (0.96), with a p value at 0.003, when compared with CEA.