Table 2.
Plasma and urine creatinine–indexed urine biomarker concentrations according to development of contrast-associated AKI
| Biomarker | Median (Interquartile Range) Plasma Biomarker, pg/ml | Median (Interquartile Range) Urine Creatinine–Indexed Urine Biomarker, pg/mg | ||||||
|---|---|---|---|---|---|---|---|---|
| Contrast-Associated Acute Kidney Injury | No Contrast-Associated Acute Kidney Injury | Unadjusted P Value | Adjusted P Valuea | Contrast-Associated Acute Kidney Injury | No Contrast-Associated Acute Kidney Injury | Unadjusted P Value | Adjusted P Valuea | |
| Preangiography | ||||||||
| KIM-1 | 430 (295, 713) | 319 (190, 593) | 0.002 | 0.004 | 16 (10, 28) | 16 (9, 27) | 0.48 | 0.43 |
| NGAL | 232 (168, 297) | 230 (175, 299) | 0.89 | 0.55 | 0.3 (0.1, 0.4) | 0.2 (0.1, 0.5) | 0.91 | 0.60 |
| IL-18 | 347 (265, 447) | 316 (245, 408) | 0.09 | 0.12 | 0.2 (0.1, 0.4) | 0.2 (0.2, 0.4) | 0.70 | 0.46 |
| MCP-1 | 218 (168, 265) | 218 (181, 271) | 0.46 | 0.31 | 2 (2, 3) | 2 (1, 3) | 0.74 | 0.87 |
| UMOD | 68 (49, 87) | 71 (50, 97) | 0.28 | 0.26 | 32 (16, 57) | 25 (15, 48) | 0.08 | 0.13 |
| YKL-40 | 108,251 (54,743, 205,041) | 94,598 (54,166, 178,090) | 0.41 | 0.50 | 4 (2, 17) | 4 (2, 12) | 0.71 | 0.99 |
| Postangiography | ||||||||
| KIM-1 | 428 (248, 745) | 306 (179, 567) | 0.006 | 0.04 | 16 (10, 26) | 13 (7, 23) | 0.06 | 0.04 |
| NGAL | 225 (158, 271) | 206 (157, 269) | 0.73 | 0.96 | 0.3 (0.2, 0.6) | 0.3 (0.1, 0.6) | 0.74 | 0.46 |
| IL-18 | 325 (247, 422) | 280 (212, 366) | 0.004 | 0.009 | 0.2 (0.2, 0.3) | 0.2 (0.2, 0.4) | 0.39 | 0.15 |
| MCP-1 | 194 (170, 254) | 209 (175, 260) | 0.15 | 0.09 | 2 (2, 4) | 2 (1, 4) | 0.68 | 0.60 |
| UMOD | 66 (49, 87) | 66 (47, 91) | 0.91 | 0.80 | 35 (25, 43) | 30 (21, 39) | 0.02 | 0.04 |
| YKL-40 | 97,570 (55,914, 216,946) | 82,268 (47,238, 154,878) | 0.13 | 0.23 | 9 (4, 33) | 9 (4, 22) | 0.85 | 0.84 |
| Absolute change | ||||||||
| KIM-1 | −18 (−63, 27) | −18 (−51, 5) | 0.63 | 0.43 | −1 (−5, 1) | −1 (−6, 2) | 0.80 | 0.70 |
| NGAL | −23 (−47, −3) | −20 (−45, 1) | 0.62 | 0.43 | 0 (−0, 0) | 0 (−0, 0) | 0.55 | 0.52 |
| IL-18 | −30 (−71, −9) | −27 (−53, −10) | 0.58 | 0.62 | 0 (−0, 0) | 0 (−0, 0) | 0.98 | 0.94 |
| MCP-1 | −6 (−32, 17) | −6 (−40, 32) | 0.37 | 0.30 | −0 (−0, 1) | 0 (−0, 0) | 0.70 | 0.72 |
| UMOD | −4 (−9, 0) | −4 (−11, 0) | 0.52 | 0.28 | −0 (−18, 15) | 1 (−12, 13) | 0.90 | 0.80 |
| YKL-40 | −13,128 (−32,783, −2162) | −10,235 (−24,532,−2189) | 0.34 | 0.37 | 3 (1, 8) | 3 (1, 9) | 0.82 | 0.88 |
| Relative ratio | ||||||||
| KIM-1 | 0.96 (0.87, 1.05) | 0.94 (0.87, 1.02) | 0.50 | 0.41 | 0.89 (0.76, 1.09) | 0.91 (0.66, 1.11) | 0.82 | 0.80 |
| NGAL | 0.90 (0.82, 0.99) | 0.91 (0.81, 1.00) | 0.76 | 0.59 | 1.26 (0.86, 1.93) | 1.15 (0.82, 1.68) | 0.35 | 0.38 |
| IL-18 | 0.91 (0.86, 0.97) | 0.91 (0.85, 0.96) | 0.53 | 0.54 | 1.03 (0.83, 1.48) | 1.02 (0.79, 1.40) | 0.71 | 0.89 |
| MCP-1 | 0.97 (0.84, 1.10) | 0.97 (0.83, 1.17) | 0.34 | 0.33 | 0.99 (0.83, 1.25) | 1.01 (0.81, 1.25) | 0.86 | 0.92 |
| UMOD | 0.94 (0.89, 1.00) | 0.93 (0.85, 1.01) | 0.22 | 0.14 | 0.97 (0.59, 1.71) | 1.07 (0.68, 1.74) | 0.68 | 0.48 |
| YKL-40 | 0.88 (0.78, 0.96) | 0.87 (0.78, 0.96) | 0.66 | 0.79 | 1.77 (1.19, 4.31) | 1.71 (1.16, 4.19) | 0.94 | 0.95 |
KIM-1, kidney injury molecule-1; NGAL, neutrophil gelatinase-associated lipocalin; MCP-1, monocyte chemoattractant protein-1; UMOD, uromodulin.
a
Adjusted for baseline eGFR and urine albumin-creatinine ratio