Table 3.
Plasma and urine creatinine–indexed urine biomarker concentrations according to development of major adverse kidney events or death
| Biomarker | Median (Interquartile Range) Plasma Biomarker, pg/ml | Median (Interquartile Range) Urine Creatinine–Indexed Urine Biomarker, pg/mg | ||||
|---|---|---|---|---|---|---|
| Major Adverse Kidney Events or Death | No Major Adverse Kidney Events or Death | Adjusted P Valuea | Major Adverse Kidney Events or Death | No Major Adverse Kidney Events or Death | Adjusted P Valuea | |
| Preangiography | ||||||
| KIM-1 | 504 (306, 948) | 321 (189, 585) | 0.04 | 18 (12, 41) | 16 (9, 26) | 0.11 |
| NGAL | 259 (209, 420) | 228 (173, 296) | 0.04 | 0.5 (0.2, 2) | 0.2 (0.1, 0.5) | 0.16 |
| IL-18 | 332 (238, 446) | 318 (246, 408) | 0.86 | 0.4 (0.2, 0.7) | 0.2 (0.1, 0.4) | 0.002 |
| MCP-1 | 229 (167, 280) | 217 (181, 270) | 0.94 | 3 (2, 6) | 2 (2, 3) | 0.03 |
| UMOD | 59 (41, 81) | 71 (51, 97) | 0.01 | 29 (14, 39) | 25 (15, 49) | 0.90 |
| YKL-40 | 141,987 (98,750, 284,819) | 91,371 (53,545, 174,700) | 0.001 | 10 (3, 44) | 4 (1, 11) | 0.008 |
| Postangiography | ||||||
| KIM-1 | 505 (299, 885) | 299 (175, 557) | 0.02 | 17 (12, 45) | 13 (7, 22) | 0.03 |
| NGAL | 238 (194, 343) | 202 (156, 265) | 0.02 | 0.4 (0.2, 1.2) | 0.3 (0.1, 0.6) | 0.27 |
| IL-18 | 304 (208, 390) | 284 (216, 367) | 0.69 | 0.4 (0.2, 0.6) | 0.2 (0.2, 0.4) | <0.001 |
| MCP-1 | 205 (166, 235) | 209 (175, 261) | 0.51 | 4 (2, 6) | 2 (1, 3) | 0.01 |
| UMOD | 60 (43, 79) | 67 (48, 91) | 0.04 | 28 (18, 35) | 30 (21, 40) | 0.42 |
| YKL-40 | 126,938 (80,109, 268,256) | 80,593 (46,350, 15,369) | <0.001 | 21 (8, 78) | 8 (4, 21) | 0.02 |
| Absolute change | ||||||
| KIM-1 | −22 (−102, 7) | −17 (−49, 6) | 0.47 | −1 (−5, 4) | −1 (−6, 1) | 0.29 |
| NGAL | −19 (−58, −1) | −20 (−45, 0) | 0.67 | 0.01 (−0.1, 0.1) | 0.03 (−0.04, 0.2) | 0.10 |
| IL-18 | −26 (−59, −6) | −27 (−53, −10) | 0.68 | 0.002 (−0.1, 0.07) | 0.01 (−0.06, 0.08) | 0.89 |
| MCP-1 | −7 (−31, 29) | −6 (−40, 29) | 0.78 | 0.07 (−0.4, 1.1) | 0.01 (−0.4, 0.5) | 0.51 |
| UMOD | −3 (−7, 1) | −4 (−11, 0) | 0.17 | −0.6 (−9, 5) | 1.5 (−13, 13) | 0.50 |
| YKL-40 | −10,513 (−26,799, 2237) | −10,306 (−24,742, −2231) | 0.47 | 5 (0.8, 15) | 3.0 (0.9, 8.3) | 0.63 |
| Relative ratio | ||||||
| KIM-1 | 0.95 (0.90, 1.03) | 0.94 (0.87, 1.02) | 0.76 | 0.95 (0.79, 1.18) | 0.90 (0.66, 1.10) | 0.30 |
| NGAL | 0.92 (0.83, 1.00) | 0.91 (0.81, 1.00) | 0.89 | 1.05 (0.79, 1.26) | 1.16 (0.83, 1.74) | 0.08 |
| IL-18 | 0.92 (0.87, 0.97) | 0.91 (0.85, 0.96) | 0.29 | 1.01 (0.82, 1.43) | 1.03 (0.79, 1.41) | 0.80 |
| MCP-1 | 0.96 (0.83, 1.15) | 0.97 (0.83, 1.16) | 0.79 | 1.02 (0.85, 1.30) | 1.01 (0.81, 1.25) | 0.38 |
| UMOD | 0.95 (0.88, 1.02) | 0.93 (0.85, 1.01) | 0.21 | 0.98 (0.73, 1.30) | 1.08 (0.68, 1.76) | 0.37 |
| YKL-40 | 0.92 (0.84, 1.03) | 0.87 (0.77, 0.96) | 0.007 | 1.30 (1.04, 4.28) | 1.74 (1.18, 4.23) | 0.07 |
KIM-1, kidney injury molecule-1; NGAL, neutrophil gelatinase-associated lipocalin; MCP-1, monocyte chemoattractant protein-1; UMOD, uromodulin.
a
Adjusted for baseline eGFR and urine albumin-creatinine ratio.