Figure 3.

The relationship between CKD and preeclampsia includes a shared phenotype of endothelial dysfunction, chronic hypertension and proteinuria, adverse pregnancy outcomes, and an increased lifetime risk of cardiovascular and kidney disease. CKD increases the risk of adverse pregnancy outcomes, and preeclampsia is associated with an increased risk of CKD, including end-stage kidney failure. Common pathophysiological mechanisms include endothelial and angiogenic dysfunction, podocyte loss, complement activation, and RAS activation. CV, cardiovascular; RAS, renin-angiotensin system.