Table 1.
Baseline clinical and histologic characteristics
| Variable | Total, n=97 | C3 GN, n=81 | Dense Deposit Disease, n=16 |
|---|---|---|---|
| Baseline | |||
| Age at diagnosis, yr | 32±21 | 34±21 | 22±15 |
| Adult/pediatric, % | 74/26 | 74/26 | 69/31 |
| Men, n (%) | 54 (56) | 49 (61) | 5 (31) |
| Antecedent infection, n (%) | 26 (27) | 21 (26) | 5 (31) |
| Clinical presentation, n (%) | |||
| Nephrotic syndrome | 39 (40) | 32 (39) | 7 (44) |
| Nephritic syndrome | 29 (30) | 26 (32) | 3 (19) |
| Asymptomatic urinary abnormalities | 29 (30) | 23 (28) | 6 (38) |
| Serum creatinine, mg/dl | 1.5 [0.8–3] | 1.5 [0.8–3] | 1.1 [0.6–3.1] |
| eGFR at baseline, ml/min per 1.73 m2 | 55 [20–120] | 53 [20–116] | 85 [26–134] |
| eGFR ranges, ml/min per 1.73 m2, n (%) | |||
| ≥60 | 41 (42) | 32 (40) | 9 (56) |
| 30–59 | 21 (22) | 18 (22) | 13 (19) |
| <30 | 35 (36) | 31 (38) | 4 (25) |
| Albumin, g/dl | 3±0.8 | 3.1±0.8 | 3±0.8 |
| Proteinuria, g/24 h | 3 [1.6–6.8] | 3 [1.5–6.8] | 3.6 [1.8–7.9] |
| Serum C3, mg/dla | 61±40 | 63±41 | 48±35 |
| Low serum C3, <75 mg/dl, n (%) | 66 (68) | 52 (64) | 14 (88) |
| Serum C4, mg/dlb | 24±9 | 25±9 | 23±9 |
| Serum C5b–9, mg/Lc | 360 (170–828) | 294 (160–781) | 497 (329–1276) |
| Elevated serum C5b-9, >100 mg/L, n (%) | 82 (84) | 67 (82) | 15 (94) |
| Histopathology | |||
| Light microscopy pattern, n (%) | |||
| Membranoproliferative GN | 70 (73) | 55 (68) | 15 (94) |
| Diffuse endocapillary proliferative GN | 7 (7) | 7 (9) | 0 (0) |
| Mesangial proliferative GN | 15 (15) | 14 (17) | 1 (6) |
| Diffuse sclerosing GN | 5 (5) | 5 (6) | 0 (0) |
| Globally sclerotic glomeruli, % | 7 [0–24] | 6 [0–24] | 12 [0–35] |
| Segmental sclerotic glomeruli, n (%) | 15 (15) | 11 (14) | 4 (25) |
| Cellular or fibrocellular crescents, n (%) | 24 (25) | 21 (26) | 3 (19) |
| Tubular atrophy/interstitial fibrosis, n % | |||
| Absence | 36 (37) | 30 (37) | 6 (38) |
| Mild | 32 (33) | 29 (36) | 3 (19) |
| Moderate | 19 (20) | 14 (17) | 5 (31) |
| Severe | 10 (10) | 8 (10) | 2 (13) |
| Arterio- and arteriolosclerosis, n (%) | 24 (25) | 19 (24) | 5 (31) |
Continuous variables are presented as mean±SD, or median [interquartile range].
a
Reference values: 75–135.
b
Reference values: 14–60.
c
Reference values: <100.