Table 2.
List of commercial companies that use exosomes for therapies.
| Company name | Product/therapy description | URL |
|---|---|---|
| Aegle Therapeutics | Phase 1/2a clinical trial of MSC-derived exosomes to treat severe dermatological disorders. | https://www.aegletherapeutics.com/index.html |
| Anjarium Biosciences | Hybridosome™ platform for vesicle modification to provide additional specificity and biodistribution. | http://www.anjarium.com |
| ArunA Biomedical | Neural exosomes to treat various central nervous system and neurodegenerative disorders. | https://arunabio.com |
| BioVision Incorporated | Production of exosome quantification, isolation, and
DNA/RNA extraction kits. Production of disease-specific exosomal marker antibodies. |
https://www.biovision.com |
| Capricor Therapeutics | Exosomal technology for the treatment of severe, rare,
and inflammatory disorders at a clinical level. Exosomes isolated from chromosphere-derived cells. |
http://capricor.com |
| Codiak Biosciences | Engineered exosomes for precise
targeting. Industrial quality and scale of exosomes for clinical applications. |
http://www.codiakbio.com |
| Evox Therapeutics | Targeting technology, manufacturing, and purification
methods for transformational therapeutics. Molecular engineering, drug loading, and targeting strategies. |
https://www.evoxtherapeutics.com |
| Exogenus | Exosome-based drug development for the treatment of skin and autoimmune diseases. | http://www.exogenus-t.com |
| Exopharm | Development of Ligand-based Exosome Affinity Purification (LEAP) technology to isolate exosomes using affinity chromatography. | https://exopharm.com |
| Exosome Diagnostics | Detection, diagnosis, treatment, and monitoring of
cancer and other diseases. Serum/plasma and urine kits for biomarker discovery, liquid biopsy, clinical diagnostic development, and targeted therapies. |
http://www.exosomedx.com |
| Exosome Sciences | Exosome-based biomarkers to diagnose Alzheimer’s,
Chronic Traumatic Encephalopathy, and other neurological
disorders. Development of the TauSome™ biomarker used in blood testing to identify Chronic Traumatic Encephalopathy. |
https://www.exosomesciences.com |
| Exosomics | Biofluid tests for cancer screening and liquid biopsy
using tumour exosomes. Development of tumour-derived DNA/RNA from exosomes and cancer-derived exosome standards. |
https://www.exosomics.it |
| Kimera Labs | Development of purified placental MSC exosomes for research and therapeutic purposes, including wound healing and immunological manipulation. | https://kimeralabs.com |
| ReNeuron | Pre-clinical development of permanent stem cell line, CTX, -derived exosomes. | http://www.reneuron.com |
| Tavec Pharma | Pre-clinical development of injectable miRNA-loaded exosomes to reduce cholangiocarcinoma tumours. | http://tavecpharma.com |