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. 2020 Jul 13;9(1):1790159. doi: 10.1080/20013078.2020.1790159

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Dsg2 alters IL-8 and IRAK1 through miR-146a. (A) The expression of 93 total cellular and 19 EV miRNAs altered in response to Dsg2 detected by RNASeq (signal > 500 and P = 0.05) as reflected by log-normalised intensities. [(B) and (C)] SCC A341 cells were treated with scrambled control, miR-146a mimic or miR-146a inhibitor for 24 h and total RNA was isolated. RT-qPCR performed for IL-8 (B) and IRAK1 (C) and expression levels were normalised to GAPDH (N = 9). For IL-8: Untreated, 1.0 ± 0.2; Scramble, 1.4 ± 0.2; Mimic 0.4 ± 0.3; Inhibitor, 1.7 ± 0.1. For IRAK1: Untreated, 1.0 ± 0.5; Scramble, 1.3 ± 0.9; Mimic 0.35 ± 0.1; Inhibitor 7.1 ± 04.1.