Table 3.

Dsg2-dependent miRNA changes in cells and EVs. RNAseq data for miRNA expression in A431 SCC cells in response to Dsg2. Complete list of 93 cellular and 19 EV miRNAs modified in response to Dsg2.

Cells			Extracellular vesicles
miRNA	P value	Fold change	miRNA	P value	Fold change
hsa-miR-4751	3.4E-02	3.494971	hsa-miR-148a-5p	2.6E-02	3.160165
hsa-miR-3614-3p	2.4E-02	3.457813	hsa-miR-1249-3p	8.0E-04	3.010493
hsa-miR-155-5p	1.6E-02	2.466088	hsa-miR-155-5p	5.5E-02	2.948538
hsa-miR-489-3p	4.7E-02	2.396844	hsa-miR-574-3p	2.6E-02	2.394957
hsa-miR-1343-3p	1.4E-02	2.178318	hsa-miR-1237-5p	7.7E-03	2.361985
hsa-miR-335-3p	2.2E-02	2.173783	hsa-miR-1296-5p	3.7E-02	2.329467
hsa-miR-1268b	1.7E-02	2.08478	hsa-miR-4746-5p	4.8E-02	2.265768
hsa-miR-941	3.7E-03	2.015638	hsa-miR-589-5p	5.1E-02	2.114036
hsa-miR-1303	4.3E-03	2.006902	hsa-miR-486-5p	4.1E-02	1.931873
hsa-miR-550a-3-5p	5.4E-02	1.988431	hsa-miR-210-3p	5.3E-02	1.905276
hsa-miR-339-5p	2.0E-02	1.978894	hsa-miR-769-5p	5.4E-02	1.547565
hsa-miR-125b-5p	3.7E-02	1.936007	hsa-miR-25-3p	1.4E-02	1.375542
hsa-miR-345-5p	1.5E-03	1.921073	hsa-miR-30d-5p	3.3E-02	1.301342
hsa-miR-378a-5p	5.2E-02	1.901527	hsa-let-7a-5p	0.0E + 00	1.265757
hsa-miR-222-3p	2.3E-02	1.859522	hsa-miR-328-3p	2.1E-02	1.172835
hsa-miR-455-3p	8.7E-03	1.854454	hsa-miR-95-3p	3.7E-02	1.132884
hsa-miR-3935	4.4E-02	1.842817	hsa-miR-103a-3p	5.3E-02	−1.10957
hsa-miR-1268a	3.3E-03	1.824421	hsa-miR-181a-2-3p	1.9E-03	−1.60214
hsa-miR-3158-3p	1.6E-02	1.778372	hsa-miR-146a-5p	4.5E-02	−7.72749
hsa-miR-424-3p	4.3E-02	1.763534
hsa-miR-4530	2.4E-02	1.75379
hsa-miR-3908	1.9E-02	1.738225
hsa-miR-30d-5p	4.0E-02	1.723596
hsa-miR-4746-5p	2.1E-02	1.711908
hsa-miR-185-3p	2.1E-02	1.70947
hsa-miR-589-5p	9.2E-03	1.703309
hsa-miR-574-3p	3.5E-02	1.671365
hsa-miR-181a-5p	2.9E-02	1.631138
hsa-miR-614	2.9E-02	1.625194
hsa-miR-4745-5p	3.6E-02	1.621327
hsa-miR-100-5p	3.7E-02	1.600418
hsa-miR-193b-3p	3.2E-02	1.578689
hsa-miR-6822-3p	4.7E-02	1.558634
hsa-miR-1275	2.2E-02	1.546801
hsa-miR-1260b	3.1E-02	1.53002
hsa-miR-181a-2-3p	1.3E-02	1.509715
hsa-miR-218-1-3p	3.3E-05	1.496705
hsa-miR-1249-3p	6.0E-03	1.493437
hsa-miR-210-5p	4.2E-02	1.480334
hsa-miR-423-3p	2.2E-02	1.457199
hsa-miR-125a-3p	2.2E-02	1.452636
hsa-miR-4286	5.0E-02	1.416065
hsa-miR-675-5p	4.0E-02	1.398583
hsa-miR-520g-5p	1.2E-02	1.354219
hsa-miR-483-3p	1.1E-02	1.28771
hsa-miR-937-3p	5.4E-03	1.24022
hsa-miR-221-3p	3.6E-02	1.239406
hsa-miR-17-5p	5.1E-02	1.162815
hsa-miR-548av-5p	7.8E-03	1.157471
hsa-miR-548k	7.8E-03	1.157471
hsa-miR-181d-5p	2.2E-03	−1.090434
hsa-miR-4315	5.1E-03	−1.093118
hsa-miR-151a-3p	2.7E-02	−1.169172
hsa-miR-4443	2.6E-02	−1.244754
hsa-miR-224-5p	2.8E-02	−1.255403
hsa-miR-130a-3p	2.8E-02	−1.267563
hsa-miR-218-5p	4.5E-02	−1.325368
hsa-miR-452-5p	5.2E-02	−1.32573
hsa-miR-27a-3p	8.7E-03	−1.378141
hsa-miR-30b-5p	5.5E-02	−1.385742
hsa-miR-26b-5p	5.7E-03	−1.409554
hsa-miR-200a-3p	4.2E-04	−1.432015
hsa-miR-6718-5p	2.6E-02	−1.436837
hsa-miR-455-5p	3.1E-02	−1.503326
hsa-miR-16-2-3p	2.6E-02	−1.512259
hsa-miR-4283	2.8E-03	−1.559243
hsa-miR-141-3p	7.3E-03	−1.571711
hsa-miR-30c-5p	1.2E-02	−1.624972
hsa-miR-4322	3.9E-02	−1.723357
hsa-miR-7641	3.1E-02	−1.723383
hsa-miR-99a-5p	2.1E-02	−1.799487
hsa-miR-4675	3.7E-05	−1.815564
hsa-miR-203a-3p	8.3E-03	−1.824814
hsa-miR-98-5p	8.7E-03	−1.831834
hsa-miR-101-3p	1.5E-02	−1.843259
hsa-miR-454-3p	1.4E-02	−1.865915
hsa-miR-29c-3p	4.1E-02	−1.909977
hsa-miR-10a-3p	1.1E-02	−1.942635
hsa-miR-194-5p	1.5E-02	−1.956922
hsa-miR-10a-5p	2.2E-03	−1.968513
hsa-miR-301b-3p	3.7E-02	−2.007348
hsa-miR-19a-3p	1.5E-02	−2.043948
hsa-miR-21-5p	4.5E-02	−2.049397
hsa-let-7c-5p	2.9E-02	−2.054183
hsa-miR-10b-5p	2.3E-04	−2.183278
hsa-miR-944	1.1E-02	−2.186209
hsa-miR-374a-5p	1.1E-05	−2.355238
hsa-miR-4664-5p	3.4E-02	−2.532697
hsa-miR-497-5p	2.8E-02	−2.590796
hsa-miR-192-5p	3.0E-02	−2.808976
hsa-miR-301a-3p	4.4E-03	−2.928572
hsa-miR-342-3p	3.0E-05	−4.24184
hsa-miR-146a-5p	1.0E-03	−13.1954