Table 3.
25 most relevant pathways over-represented in reactome analysis.
| Entities |
Reactions |
|||
|---|---|---|---|---|
| Pathway name | Found/total | p value | FDR | Found/total |
| Formation of the ternary complex, and subsequently, the 43S complex | 35/52 | 1.11E-16 | 4.11E-15 | 3/3 |
| Translation initiation complex formation | 39/59 | 1.11E-16 | 4.11E-15 | 2/2 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 39/60 | 1.11E-16 | 4.11E-15 | 6/6 |
| Ribosomal scanning and start codon recognition | 38/59 | 1.11E-16 | 4.11E-15 | 2/2 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | 36/56 | 1.11E-16 | 4.11E-15 | 4/4 |
| Peptide chain elongation | 57/90 | 1.11E-16 | 4.11E-15 | 5/5 |
| Eukaryotic Translation Elongation | 59/95 | 1.11E-16 | 4.11E-15 | 9/9 |
| Formation of a pool of free 40S subunits | 63/102 | 1.11E-16 | 4.11E-15 | 2/2 |
| Eukaryotic Translation Termination | 57/94 | 1.11E-16 | 4.11E-15 | 5/5 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 58/96 | 1.11E-16 | 4.11E-15 | 1/1 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 68/113 | 1.11E-16 | 4.11E-15 | 3/3 |
| Cap-dependent Translation Initiation | 69/120 | 1.11E-16 | 4.11E-15 | 18/18 |
| Viral mRNA Translation | 55/101 | 1.11E-16 | 4.11E-15 | 2/2 |
| Nonsense-Mediated Decay (NMD) | 60/117 | 1.11E-16 | 4.11E-15 | 6/6 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 60/117 | 1.11E-16 | 4.11E-15 | 5/5 |
| SRP-dependent co-translational protein targeting to membrane | 55/113 | 1.11E-16 | 4.11E-15 | 5/5 |
| Neutrophil degranulation | 144/480 | 1.11E-16 | 4.11E-15 | 10/10 |
| Eukaryotic Translation Initiation | 69/120 | 1.11E-16 | 4.11E-15 | 20/21 |
| Membrane Trafficking | 141/635 | 1.11E-16 | 4.11E-15 | 169/218 |
| Vesicle-mediated transport | 177/761 | 1.11E-16 | 4.11E-15 | 191/251 |
| RHO GTPase Effectors | 83/295 | 1.11E-16 | 4.11E-15 | 85/112 |
| ER-Phagosome pathway | 60/153 | 1.11E-16 | 4.11E-15 | 7/10 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 69/112 | 1.11E-16 | 4.11E-15 | 2/3 |
| Antigen processing-Cross presentation | 62/169 | 1.11E-16 | 4.11E-15 | 14/22 |
| Translation | 94/294 | 1.11E-16 | 4.11E-15 | 61/99 |