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. 2020 Jun 16;9(1):1778883. doi: 10.1080/20013078.2020.1778883

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Histological evaluation of cartilage defect repaired by Gel-nano-sEVs hydrogel. (a) Macroscopic observation of cartilage defect at 12 weeks postsurgery. (b) ICRS macroscopic scores of different groups. Data were presented as mean ± SD of three number of replicates. t-test was applied to each group in order to compare mean beta values. n = 6, ***P < 0.001. (c) Safranin O/fast green staining of repaired cartilage. Scale bar = 250 um. (d) HE staining of repaired cartilage. Scale bar = 250 um. (e) Immunohistochemical staining of collagen II. Scale bar = 125 um. (f) Quantitative analysis of immunohistochemical staining of collagen II. (g) ICRS visual histological scores of different groups. Data were presented as mean ± SD of three number of replicates. t-test was applied to each group in order to compare mean beta values. n = 6, ***P < 0.001.