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. 2020 Jun 16;9(1):1778883. doi: 10.1080/20013078.2020.1778883

Scheme 1.

Scheme 1.

Schematic illustration of therapeutic sEVs released from Gelma/nanoclay hydrogel for cartilage regeneration. (a) Preparation of Gelma/nanoclay/sEVs hydrogel and cartilage defect implantation. (b) Sustained release of sEVs with the degradation of hydrogel. (c) Internalization of therapeutic sEVs by chondrocytes and hBMSCs. (d) The effect of sEVs on chondrocytes and hBMSCs. (e) Regeneration of cartilage defect by the composited hydrogel.