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. 2020 Jul 13;9(1):1790874. doi: 10.1080/20013078.2020.1790874

Figure 4.

Figure 4.

Early and late MEx administration improves peripheral pulmonary blood vessel count and pulmonary vascular muscularization. Long-term outcomes were assessed at PN60. Harvested lung sections were stained von Willebrand factor (vWF) (a) or α-smooth muscle actin (α-SMA) (c) to assess the effect of HYRX on peripheral pulmonary blood vessel loss and pulmonary vascular remodelling, respectively. Arrows highlight vWF-stained pulmonary vessels. (b) For quantification of blood vessels, values are expressed as the average blood vessel count per field. (d) Medial thickness index (MTI) = 100 × (area[ext] – area[int])/area[ext]). Area[ext] and area[int] denote the areas within the external and internal boundaries of the α-SMA layer, respectively. vWF scale bar = 100 μm. α-SMA scale bar = 75 μm. n = 6–12 per group. *p < 0.05, #p < 0.001, $p < 0.0001 vs. HYRX group.