FIG. 2.

Effect of cannabis extract treatment on glucose tolerance in mice fed high-fat atherogenic diet. Male C57BL/6J mice aged 7–8 weeks were fed HFCD. Mice were intubated three times a week with CN1 or CN2 or CN6 cannabis extracts in concentrations of 5 mg/kg body weight for 6 weeks. OGTT was performed at week 5 with blood sampled from mouse tail tips. (A) Glucose levels between 0 and 120 during OGTT. (B) Area under the curve of graph A. (C) Insulin serum levels at sacrifice. All values are expressed as mean±SEM (n=8). Columns and graphs marked with different letters (a, b) are significantly different (p<0.05) in the Tukey–Kramer post hoc test. AUC, area under the curve; OGTT, oral glucose tolerance test.