Table 3.
Genotype and allele frequencies of vitamin D receptor single nucleotide polymorphism (VDR SNPs) in women with SPTB and controls*
| N (%) of |
|||||||
|---|---|---|---|---|---|---|---|
| VDR SNP | women with SPTB | controls | X2 | P | OR (95% CI) | P | |
|
FokI |
Genotype |
||||||
| CC |
41 (34.7) |
36 (30.2) |
1.23 |
0.540 |
reference |
||
| CT |
59 (50) |
68 (57.1) |
1.31 (0.74-2.31) |
0.347 |
|||
| TT |
18 (15.2) |
15 (12.6) |
0.95 (0.42-2.15) |
0.900 |
|||
| Allele |
|||||||
| C |
141 (59.7) |
140 (58.8) |
0.01 |
0.912 |
reference |
||
| T |
95(40.3) |
98 (41.2) |
1.04 (0.72-1.50) |
0.838 |
|||
|
ApaI |
Genotype |
||||||
| TG |
63 (53.4) |
63 (52.9) |
0.44 |
0.803 |
reference |
||
| GG |
30 (25.4) |
34 (28.6) |
1.13 (0.62-2.07) |
0.684 |
|||
| TT |
25 (21.2) |
22 (18.5) |
0.88 (0.45-1.72) |
0.709 |
|||
| Allele |
|||||||
| T |
113 (47.9) |
157 (65.9) |
2.03 |
0.155 |
reference |
||
| G |
123 (52.1) |
131 (55.0) |
0.77 (0.54-1.08) |
0.131 |
|||
|
Bsml |
Genotype |
||||||
| GG |
47 (39.8) |
45 (37.8) |
0.41 |
0.813 |
reference |
||
| AG |
58 (49.1) |
63 (52.0) |
1.13 (0.66-1.95) |
0.788 |
|||
| AA |
13 (11.0) |
11 (9.2) |
0.88 (0.36-2.17) |
0.648 |
|||
| Allele |
|||||||
| A |
152 (64.4) |
153 (64.3) |
0.00 |
0.945 |
reference |
||
| G |
84 (35.6) |
85 (35.7) |
1.00 (0.69-1.46) |
0.978 |
|||
|
TaqI |
Genotype |
||||||
| TT |
53 (44.9) |
56 (47.0) |
0.84 |
0.655 |
reference |
||
| CT |
52 (44.0) |
54 (45.4) |
0.98 (0.57-1.68) |
0.949 |
|||
| CC |
13 (11.0) |
9 (7.6) |
0.65 (0.26-1.66) |
0.372 |
|||
| Allele |
|||||||
| T |
158 (66.9) |
166 (69.7) |
0.31 |
0.578 |
reference |
||
| C |
78 (33.0) |
72 (30.2) |
0.88 (0.60-1.29) |
0.512 |
|||
| Cdx2 | Genotype |
||||||
| GG |
80 (67.8) |
84 (70.6) |
0.61 |
0.737 |
reference |
||
| AG |
33 (27.9) |
32 (23.9) |
0.92 (0.52-1.64) |
0.786 |
|||
| AA |
5 (4.2) |
3 (2.5) |
0.57 (0.13-2.47) |
0.454 |
|||
| Allele |
|||||||
| G |
193 (81.8) |
200 (84.0) |
0.28 | 0.596 | reference |
||
| A | 43 (18.2) | 38 (15.9) | 0.85 (0.53-1.38) | 0.515 | |||
*CI – confidence interval; OR – odds ratio; SNP – single nucleotide polymorphism; SPTB – spontaneous preterm birth.