Table 1.
Summary of the data depicted in Figure 2. Included events should not be considered comprehensive of the literature: our goal was simply to include markers for major structural and biochemical changes. Studies were included if they contained at least time points between postnatal days 0–60 (translated to rat). Descriptive functions were generated using standard functions (Weibull, Gaussian, exponential) and were fitted based on standard function minimization (code available at https://github.com/VisCog/plasticity-molecules-to-behavior).
| Mechanisms | Data | Species | Reference |
|---|---|---|---|
| Maturation of the excitatory network, Figure 2A | |||
| PYR: Spine Density | Spine density (at a distance 50–60μm from the soma) | Macaque monkey | [26] Figure 4C |
| PYR: Conversion to Stellate | Ratio of stellate: pyramidal spiny neurons. At eye opening, no pyramidal stellate cells exist. By adulthood 78% of spiny cells are classified as stellate. | Ferret | [27] Figure 4D |
| NMDA: GluN1 | NMDA receptor subunit GluN1 | Mouse | [28] Figure 3C |
| NMDA: EPSP | Speed (half width) of NMDA-mediated EPSP under blockade of non-NMDA receptors | Cat | [29] Figure 7A |
| Maturation of the inhibitory network, Figure 2B | |||
| PSA | Polysialic acid (PSA) expression | Mouse | [30] Figure 1 |
| PV: Number | Number of PV cells | Mouse | [31] Figure 4B |
| GABA-Aα1 | GABA-A receptor subunit α1 | Mouse | [28] Figure 3A |
| GABA: GAD65 | GAD65 expression in presynaptic boutons of inhibitory interneurons | Mouse | Data from [31] replotted in [34] |
| Excitatory/Inhibitory balance, Figure 2C | |||
| E/I Ratio | Spontaneous EPSC / spontaneous IPSC charge. Data averaged across layers. | Rat | [37] Figure 3 |
| Maturation of silent synapses and structural stabilization, Figure 2D | |||
| SS: Propn Active | Proportion non-silent synapses. At postnatal day 3 only 20% of synapses are active, increasing to over 90% at PN 57. | Mouse | [28] Figure 2D [39] Figure S1 |
| Spines/Filipodia % | % Spines / Filopodia | Mouse | [41] Figure 1 |
| PSD-95 | Quantified protein level (normalized to adult) of PSD-95. One of a pair of DLG-MAGUK proteins. PSD-95 promotes and PSD-93 inhibits silent synapse development. | Mouse | [28] Figure 3A |
| BDNF | Expression of BDNF transgene | Mouse | [31] Figure 1 |
| PNN | Percentage of PV/WFA/PTPσ positive cells among PV cells | Rat | [44] Figure 6B |
| Sensitive vs. critical periods, Figure 2E | |||
| OSI | Orientation selectivity index | Ferret | [46] Figure 2 |
| Visual Acuity | Visual acuity (c/deg) | Rat | [48] Figure 3B |
| OD Sensitivity | Ipsilateral index. Data replotted to align to the middle of the 10-day monocular deprivation period. | Rat | [48] Figure 6B |
| Structural plasticity after the sensitive peiiod, Figure 2F | |||
| Synaptic density | Postmortem synaptic density | Human | [51] Figure 2 |