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TRIP13 remodels HORMA substrates through N-terminal engagement and is stimulated by an adaptor protein. (a) Cryo-EM structure of TRIP13 acting on C-MAD2, showing bridging by the adaptor protein, p31comet, PDB: 6F0X [89]. (b) Schematic of N-terminal engagement of HORMA substrate by TRIP13 and stimulation by an adaptor, p31comet, which bridges the interaction. Following engagement of the HORMA protein, TRIP13 catalyzes HORMA remodeling coupled to ATP hydrolysis.
