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. 2020 Aug 4;7(9):1488–1501. doi: 10.1002/acn3.51105

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© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effects of carbamazepine on M1879T channels. (A) Carbamazepine (CBZ) induces a hyperpolarizing shift of the voltage dependence of inactivation (n = 6). (B) Plot of change in inactivation V _1/2 in response to 100 and 300 µmol/L carbamazepine (n = 6; *P < 0.05 by paired t‐test). (C) Plot of residual current (comparing 300th pulse to 1st pulse) after 0 mV pulses at the indicated frequencies from a holding potential of −90 mV. There was a significant difference in residual current at 100 μmol/L (*) and 300 μmol/L (**) at 10, 25, and 50 Hz compared to the control value (P < 0.05, one‐way ANOVA with repeated measures and Dunnett’s post hoc test, n = 6). (D) Average time‐course of CBZ treated cells at 10 Hz (top), 25 Hz (middle), and 50 Hz (bottom).