Table 1.
WT (n) | M1879T (n) | M1879T‐neonatal (n) | |
---|---|---|---|
Peak current density (pA/pF) | −972 ± 151 (18) | −908 ± 163 (20) | −654 ± 125 (12) |
Inactivation time constant (τ, msec) 0 mV | 0.36 ± 0.04 (14) | 0.68 ± 0.04* (14) | 0.69 ± 0.05 † (12) |
Activation voltage dependence | |||
V 1/2 (mV) | −29.2 ± 1.7 (14) | −28.2 ± 1.8 (14) | −27.7 ± 1.2 † (14) |
Slope factor (k) | 4.8 ± 0.5 (14) | 4.5 ± 0.4 (14) | 4.8 ± 0.4 † (14) |
Inactivation voltage dependence | |||
V 1/2 (mV) | −66.3 ± 1.1 (18) | −53.8 ± 1.1* (25) | −50.3 ± 1.4 † (15) |
Slope factor (k) | −6.1 ± 0.2 (18) | −7.4 ± 0.3* (25) | −7.8 ± 0.3 † (15) |
Recovery from inactivation | |||
τ slow (msec) | 154 ± 88 (10) | 139 ± 35 (10) | 132 ± 28 † (11) |
τ fast (msec) | 2.18 ± 0.30 (10) | 2.48 ± 0.32 (10) | 2.96 ± 0.44 † (11) |
% fast component | 77.7 ± 1.8 (10) | 76.7 ± 4.4 (10) | 78.3 ± 3.1 † (11) |
Persistent current (% of peak) | |||
50 msec | 0.47 ± 0.06 (9) | 0.40 ± 0.11 (9) | 0.44 ± 0.14 † (8) |
200 msec | 0.33 ± 0.05 (9) | 0.21 ± 0.04 (9) | 0.47 ± 0.11 † (8) |
P < 0.05 by Mann–Whitney U test.
P > 0.05 between adult and neonatal isoforms.