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. 2020 Aug 4;7(9):1488–1501. doi: 10.1002/acn3.51105

Table 1.

Summary of functional properties for WT and M1879T channels.

WT (n) M1879T (n) M1879T‐neonatal (n)
Peak current density (pA/pF) −972 ± 151 (18) −908 ± 163 (20) −654 ± 125 (12)
Inactivation time constant (τ, msec) 0 mV 0.36 ± 0.04 (14) 0.68 ± 0.04* (14) 0.69 ± 0.05 (12)
Activation voltage dependence
V 1/2 (mV) −29.2 ± 1.7 (14) −28.2 ± 1.8 (14) −27.7 ± 1.2 (14)
Slope factor (k) 4.8 ± 0.5 (14) 4.5 ± 0.4 (14) 4.8 ± 0.4 (14)
Inactivation voltage dependence
V 1/2 (mV) −66.3 ± 1.1 (18) −53.8 ± 1.1* (25) −50.3 ± 1.4 (15)
Slope factor (k) −6.1 ± 0.2 (18) −7.4 ± 0.3* (25) −7.8 ± 0.3 (15)
Recovery from inactivation
τ slow (msec) 154 ± 88 (10) 139 ± 35 (10) 132 ± 28 (11)
τ fast (msec) 2.18 ± 0.30 (10) 2.48 ± 0.32 (10) 2.96 ± 0.44 (11)
% fast component 77.7 ± 1.8 (10) 76.7 ± 4.4 (10) 78.3 ± 3.1 (11)
Persistent current (% of peak)
50 msec 0.47 ± 0.06 (9) 0.40 ± 0.11 (9) 0.44 ± 0.14 (8)
200 msec 0.33 ± 0.05 (9) 0.21 ± 0.04 (9) 0.47 ± 0.11 (8)
*

P < 0.05 by Mann–Whitney U test.

P > 0.05 between adult and neonatal isoforms.